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科研机构
上海药物研究所 [104]
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期刊论文 [104]
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2021 [7]
2020 [1]
2019 [6]
2018 [13]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 页码: 6
作者:
Fan, Min
;
Wang, Ting
;
Peng, Li-Yan
;
Huang, Jun-Shang
;
Wu, Xing-De
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/11/04
Salvia hispanica
neo-clerodane diterpenoid
salvihispin H
type 2 diabetes mellitus
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Henagliflozin, a Novel Selective Inhibitor of Sodium-Glucose Cotransporter 2, in Healthy Subjects Following Single- and Multiple-dose Administration
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 2, 页码: 396-409
作者:
Zhang, Yi-fan
;
Liu, Yan-mei
;
Yu, Chen
;
Wang, Ya-ting
;
Zhan, Yan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
diabetes
henagliflozin
pharmacodynamics
pharmacokinetics
SGLT-2 inhibitors
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188, 页码: 17
作者:
Wang, Junwei
;
Lv, Xue
;
Xu, Jiawen
;
Liu, Xinpeng
;
Du, Te
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Type 2 diabetes mellitus
Pancreatic beta-cells protective agents
Vincamine derivatives
Structural modifications
Structure-activity relationships
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 43, 页码: 21732-21738
作者:
Liu, Bin
;
Zhang, Zhijian
;
Hu, Yanyun
;
Lu, Yan
;
Li, Duanzhuo
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2020/07/01
type 2 diabetes
gluconeogenesis
hepatic glucose production
ER stress
USP14
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
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