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科研机构
上海药物研究所 [66]
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期刊论文 [65]
会议论文 [1]
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2022 [1]
2020 [2]
2019 [4]
2018 [4]
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Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:
Lu, Dasheng
;
Liu, Yameng
;
Luo, Yuhong
;
Zhao, Jie
;
Feng, Chao
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/18
Fatty acid oxidation
Acylcarnitines
FXR
FGF15/19
PGC1 alpha
Transcriptomics
Metabolomics
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
期刊论文
ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596
作者:
Dou, Hui-Xia
;
Wang, Ting
;
Su, Hai-Xia
;
Gao, Ding-Ding
;
Xu, Ye-Chun
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
eFABP4
Adipocyte
Differentiation
Lipolysis
Inflammation
Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019, 期号: 10, 页码: 1396-1411
作者:
Xie, Cen
;
Takahashi, Shogo
;
Brocker, Chad N.
;
He, Shijun
;
Chen, Li
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Peroxisome proliferator-activated receptor alpha
Wy-14,643
Bile acid homeostasis
Farnesoid X receptor
Metabolomics
(5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice
期刊论文
LIFE SCIENCES, 2019, 卷号: 232, 页码: 9
作者:
Dong, Yunxia
;
Lu, Henglei
;
Li, Qiang
;
Qi, Xinming
;
Li, Yuanchao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
(5R)-5-hydroxytriptolide
NAFLD
Lipid synthesis
Fatty acids oxidation
Fat deposition
SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue
期刊论文
DIABETES, 2019, 卷号: 68, 期号: 7, 页码: 1449-1461
作者:
Shuai, Lin
;
Zhang, Li-Na
;
Li, Bo-Han
;
Tang, Chun-Lan
;
Wu, Ling-Yan
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Inhibition of HSP90 beta Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 20, 页码: 5769-5783
作者:
Zheng, Zu-Guo
;
Zhang, Xin
;
Liu, Xiao-Xiao
;
Jin, Xiu-Xiu
;
Dai, Lunzhi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
HSP90 beta
lipid metabolism
corylin
SREBPs
proteasomal degradation
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN
期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9
作者:
Liu, Bin
;
Jiang, Shangwen
;
Li, Min
;
Xiong, Xuelian
;
Zhu, Mingrui
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2019/01/08
HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1 alpha promoter
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 卷号: 85, 页码: 126-138
作者:
Xu, Xin
;
Shi, Xiaofan
;
Chen, Yidi
;
Zhou, Tingting
;
Wang, Jiaying
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
T2DM
Gluconeogenesis
FXR antagonist
PGC-1 alpha
Drug lead compound
Bavachinin analogues as agonists of pan-peroxisome proliferator-activated receptors
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2018, 卷号: 27, 期号: 7, 页码: 1851-1862
作者:
Yi, Jingyu
;
Du, Guoxin
;
Zhao, Yuanyuan
;
Zhang, Liuqiang
;
Li, Bo
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Bavachinin
Metabolic syndrome
PPARs
Reporter gene assaysThese authors contributed equally: Jingyu Yi, Guoxin Du
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