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科研机构
上海药物研究所 [30]
内容类型
期刊论文 [30]
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2021 [2]
2020 [2]
2019 [3]
2018 [1]
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Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
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  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Simultaneous determination of cinobufagin and its five metabolites in rat plasma by LC-MS/MS for characterization of metabolic profiles and pharmacokinetic study
期刊论文
ANALYTICAL METHODS, 2019, 卷号: 11, 期号: 42, 页码: 5464-5471
作者:
Wei, Wenlong
;
Li, Haojv
;
Li, Zhenwei
;
Qu, Hua
;
Da, Juan
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  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism
期刊论文
PHYTOMEDICINE, 2019, 卷号: 57, 页码: 255-261
作者:
Li Yuanmin
;
Wang Linlin
;
Dong Zhihui
;
Wang Shiying
;
Qi Lili
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Salvianolic acid B
Ginsenoside Rg1
Myocardialinfarction
Myocardial fibrosis
Cardiac remodeling
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:
Li, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
Simultaneous determination of flavonol glycoside and its major metabolites by LC-MS/MS in rat plasma
期刊论文
Acta Pharmaceutica Sinica, 2018, 卷号: 53, 期号: 8, 页码: 1344-1350
作者:
Dong Lei
;
Liu Jinqiu
;
Li Liang
;
Chen Xiaoyan
;
Shan Weiguang
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
LC-MS/MS
flavonol glycoside
glucuronide conjugate
pharmacokinetics
Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2017, 卷号: 42, 期号: 4, 页码: 593-599
作者:
Wang, Wei
;
Qian, Hong-jie
;
Xin, Liang
;
Zhang, Meng-qi
;
Lu, Dong-ying
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717
作者:
Li, He
;
Huang, Qi
;
Chen, Cheng
;
Xu, Bin
;
Wang, He-Yao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
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