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科研机构
上海药物研究所 [33]
大连化学物理研究所 [17]
复旦大学上海医学院 [12]
合肥物质科学研究院 [10]
北京大学 [5]
大连理工大学 [5]
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期刊论文 [109]
会议论文 [14]
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2017 [126]
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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Xu, Shan
;
Zhou, Yanping
;
Geng, Hui
;
Song, Dandan
;
Tang, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2018/11/05
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale
期刊论文
MICROBIOLOGYOPEN, 2017, 卷号: 6, 期号: 6, 页码: 15
作者:
Peng, Zixin
;
Li, Menghan
;
Wang, Wei
;
Liu, Hongtao
;
Fanning, Seamus
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/05/30
drug-resistance gene
Enterococcus hirae
genomic island
genomic plasticity
mobile genetic element
virulence gene
Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor
期刊论文
STEM CELL REPORTS, 2017, 卷号: 9, 期号: 6, 页码: 1813-1824
作者:
Gao, Yimeng
;
Zhang, Xiaoran
;
Zhang, Ludi
;
Cen, Jin
;
Ni, Xuan
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Critical Role of Hepatic Cyp450 sin the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Yu, Cunzhi
;
Li, Yu
;
Liu, Mingxia
;
Gao, Man
;
Li, Chenggang
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
(5R)-5-hydroxytriptolide
functional knockout
cytochrome P450
testes
gamma-H2AX
RNA polymerase II
androgen receptor
Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1
期刊论文
ACTA PHARMACEUTICA SINICA B, 2017, 卷号: 7, 期号: 6, 页码: 657-664
作者:
Cheng, Xuewei
;
Lv, Xia
;
Qu, Hengyan
;
Li, Dandan
;
Hu, Mengmeng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/06/20
Icotinib
Erlotinib
Ugt1a1
Inhibitory Effects
Drug-drug Interacts (Ddis)
Characterization, Quantification and Pharmacokinetic Analysis of Bevacizumab and Its Glycosylation by Mass Spectrometry
期刊论文
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2017, 卷号: 45, 期号: 11, 页码: 1678-1685
作者:
Ye Ming-Liang
;
Zou Han-Fa
;
Cong Yu-Ting
;
Hu Liang-Hai
;
Gu Jing-Kai
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/06/20
Bevacizumab
Glycosylation
Liquid Chromatography-tandem Mass Spectrometry
Parallel Reaction
Monitoring
Pharmacokinetics
Structure-activity relationships of flavonoids as natural inhibitors against E. coli beta-glucuronidase
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2017, 卷号: 109, 页码: 975-983
作者:
Wu, Da-Chang
;
Zou, Li-Wei
;
Dou, Tong-Yi
;
Yang, Ling
;
Zhang, Tong-Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/06/20
Flavonoids
E. Coli bE.a-glucuronidasE.
Structure-inhibition Relationships
Scutellarein
Luteolin
Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 11
作者:
Liu, Run-Zhe
;
Fan, Chao-Xin
;
Zhang, Zhi-Lin
;
Zhao, Xin
;
Sun, Yi
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/04/09
Dl-3-n-butylphthalide
Permanent Middle Cerebral Artery Occlusion (Pmcao)
Matrix-assisted Laser Desorption Time Of Flight Ionization Mass Spectrometry Imaging (maldi-tOf-ms Imaging)
Metabolites
Study of a series of fluorophore-labeled artesunate derivatives Design, analysis and application
期刊论文
DYES AND PIGMENTS, 2017, 卷号: 146, 页码: 414-419
作者:
Sun, Shiguo
;
Chen, Su-Shing
;
Liu, Fengyu
;
Ge, Guangbo
;
Yang, Zihao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2017/12/19
Artesunate (ART)
Fluorophore
Covalent modification
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