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Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12
作者:
Lin, Tingting
;
Li, Jiacheng
;
Liu, Liping
;
Li, Yuanqing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/05/24
CDK2 inhibitor
Selectivity
Anti-proliferative potency
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
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  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3234-3237
作者:
Peng, Yingyuan
;
He, Qian
;
Zhang, Xiaofei
;
Yang, Chunhao
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  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 10, 页码: 1187-1193
作者:
Sun, Liangpeng
;
Wang, Peipei
;
Xu, Lili
;
Gao, Lixin
;
Li, Jia
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  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
PTP1B inhibitor
1,3-Diphenyl-1H-pyrazole
Rhodanine-3-alkanoic acid
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:
Chen, Duo-zhi
;
Yang, Bi-juan
;
He, Xiao-li
;
Fan, Shi-rui
;
Cai, Jie-yun
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  |  
浏览/下载:113/0
  |  
提交时间:2019/03/18
Wnt/beta-catenin signalling pathway agonist
Phenanthridine derivatives
Structural optimization
Structure-activity relationships (SARs)
Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 3
作者:
Shi, Tian-Qi
;
Wang, Yan-Ting
;
Liu, Chang-Hong
;
Zhu, Hai-Liang
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Benzimidazole
Benzsulfamide
Pyrazole
Tubulin
Inhibition
Apoptosis
Molecular docking
Discovery of novel bacterial FabH inhibitors (Pyrazol-Benzimidazole amide derivatives): Design, synthesis, bioassay, molecular docking and crystal structure determination
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 171
作者:
Wang, Yan-Ting
;
Shi, Tian-Qi
;
Fu, Jie
;
Zhu, Hai-Liang
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  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
FabH
Inhibitor
Pyrazole
Antibacterial
Molecule docking
Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 3, 页码: 380-386
作者:
Dong, Junze
;
Zhang, Jingya
;
Li, Zilu
;
Asnake, Solomon
;
Zhang, Daoguang
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  |  
浏览/下载:15/0
  |  
提交时间:2019/12/11
Androgen receptor
Prostate cancer
Antagonists
Pyrazole derivatives
Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Cui, Ying-Jie
;
Tang, Long-Qian
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
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  |  
浏览/下载:122/0
  |  
提交时间:2019/12/11
privileged structure
pyrazoles
tubulin inhibitors
antitumor
antitumor agents
Discovery of novel pyrazole derivatives as potential anticancer agents in MCL
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 9, 页码: 1060-1064
作者:
Ran, Fansheng
;
Liu, Yang
;
Zhang, Daoguang
;
Liu, Meixia
;
Zhao, Guisen
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  |  
浏览/下载:28/0
  |  
提交时间:2019/12/11
Mantle cell lymphoma
BTK
Irreversible inhibitors
Anticancer
Pyrazole
derivatives
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