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Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements
期刊论文
PHYTOCHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 88-91
作者:
Huguet, Clement
;
Real, Eleonore
;
Zhao, Wei-Min
;
Urbain, Aurelie
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  |  
浏览/下载:11/0
  |  
提交时间:2021/11/04
Pregnanes
Cynanchum
Apocynaceae
Diabetes
Glucagon-like peptide-1
Structure-activity relationships
Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 46, 期号: 9, 页码: 1-12
作者:
Wei, DB (Wei, Daibao)
;
Hu, TW (Hu, Tianwen)
;
Zhang, YM (Zhang, Yumin)
;
Zheng, W (Zheng, Wei)
;
Xue, HT (Xue, Haitao)
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  |  
浏览/下载:27/0
  |  
提交时间:2021/10/14
Covid-19
SARS-CoV-2
GS-441524
Antiviral
Nucleoside
Prodrug
Isobutyrate
Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin
期刊论文
STEROIDS, 2020, 卷号: 164, 页码: 11
作者:
Zhou, Yang
;
Hou, Jinjun
;
Long, Huali
;
Zhang, Zijia
;
Lei, Min
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  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Cardiac glycosides
Cinobufagin
Natural product
Cytotoxicity
Antiproliferative activities
Synthesis and characterization of single-bond fullerene dimer derivatives
期刊论文
JOURNAL OF MATERIALS RESEARCH, 2020, 卷号: 35, 期号: 20, 页码: 2676-2683
作者:
Zhao, Hong-Quan
;
Yang, Shihan
;
Xu, Tong-Le
;
Shi, Xuan
;
Lu, Shirong
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  |  
浏览/下载:110/0
  |  
提交时间:2021/02/24
fullerene dimer derivatives
esters
absorption spectra
fluorescence spectra
photocurrent
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12
作者:
Han, Fanghui
;
Ning, Mengmeng
;
Cao, Hua
;
Ye, Yangliang
;
Feng, Ying
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  |  
浏览/下载:32/0
  |  
提交时间:2020/12/21
Soft drug
TGR5
GLP-1
Gallbladder-filling effects
Rapid metabolism
Carboxylic ester
Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta
期刊论文
STEROIDS, 2020, 卷号: 161, 页码: 5
作者:
Liu, Jiao
;
Wu, Xin
;
Yang, Min
;
Gu, Yu-Cheng
;
Yao, Li-Gong
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  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
Sinularia erecta
Steroidal derivative
Cytotoxicity
Baeyer-Villiger oxidation
Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 198, 页码: 11
作者:
Wang, Zhi-Cheng
;
Wei, Bingyan
;
Pei, Fang-Ning
;
Yang, Teng
;
Tang, Jie
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/12/24
Capsaicin
Nitrothiophene
Multidrug-resistant S. aureus
Antibacterial agent
Synthesis of oleandrin derivatives and their cytotoxic activity
期刊论文
STEROIDS, 2020, 卷号: 159, 页码: 7
作者:
Zhang, Yanzhi
;
Chen, Xubing
;
Zhou, Yang
;
Hou, Jinjun
;
Long, Huali
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
Cardiac glycosides
Oleandrin (OL)
Natural product
OL-4 '-yl ester
Cytotoxicity
Exploring Bioactive Compounds in Anaerobically Digested Slurry: Extraction, Characterization, and Assessment of Antifungal Activity
期刊论文
WASTE AND BIOMASS VALORIZATION, 2020, 卷号: 11, 期号: 5, 页码: 1863-1872
作者:
Lu, Jiaxin
;
Muhmood, Atif
;
Liu, Hongtao
;
Dong, Renjie
;
Pang, Sen
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  |  
浏览/下载:10/0
  |  
提交时间:2020/05/19
Bioactive compounds
Heterocycles
Phytopathogens
Ultrasound
Extraction
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