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科研机构
福建物质结构研究所 [15]
内容类型
期刊论文 [15]
发表日期
2011 [7]
2010 [1]
2009 [3]
2008 [2]
2007 [2]
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专题:福建物质结构研究所
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Mimicry of the Regulatory Role of Urokinase in Lamellipodia Formation by Introduction of a Non-native Interdomain Disulfide Bond in Its Receptor
期刊论文
Journal of Biological Chemistry, 2011, 卷号: 286, 期号: 50, 页码: 43515-43526
H. Gardsvoll
;
M. Kjaergaard
;
B. Jacobsen
;
M. C. Kriegbaum
;
M. D. Huang
;
M. Ploug
收藏
  |  
浏览/下载:420/0
  |  
提交时间:2012/06/06
plasminogen-activator receptor
breast-cancer
monoclonal-antibodies
cellular receptor
anthrax toxin
invasive foci
stromal cells
binding-site
in-vivo
vitronectin
Structural Basis for Therapeutic Intervention of uPA/uPAR System
期刊论文
Current Drug Targets, 2011, 卷号: 12, 期号: 12, 页码: 1729-1743
J. C. K. Ngo
;
L. G. Jiang
;
Z. H. Lin
;
C. Yuan
;
Z. Chen
;
X. Zhang
;
H. Y. Yu
;
J. D. Wang
;
L. Lin
;
M. D. Huang
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  |  
浏览/下载:73/0
  |  
提交时间:2012/06/06
uPA
uPAR
SMB
crystal structures
inhibitors
urokinase-plasminogen-activator
amino-terminal fragment
tumor-growth
cell-adhesion
receptor upar
crystal-structure
cancer-patients
deficient mice
breast-cancer
in-vivo
The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor
期刊论文
Journal of Molecular Biology, 2011, 卷号: 412, 期号: 2, 页码: 235-250
L. G. Jiang
;
A. S. P. Svane
;
H. P. Sorensen
;
J. K. Jensen
;
M. Hosseini
;
Z. Chen
;
C. Weydert
;
J. T. Nielsen
;
A. Christensen
;
C. Yuan
;
K. J. Jensen
;
N. C. Nielsen
;
A. Malmendal
;
M. D. Huang
;
P. A.
;
reasen
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  |  
浏览/下载:28/0
  |  
提交时间:2012/06/06
competitive inhibition
fibrinolysis
cancer
plasminogen activation system
sunflower seeds
urokinase
specificity
domain
compensation
compstatin
complexes
receptor
residue
Antitumor effects of cucurmosin in human chronic myeloid leukemia occur through cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
期刊论文
African Journal of Pharmacy and Pharmacology, 2011, 卷号: 5, 期号: 7, 页码: 985-992
J. M. Xie
;
W. Z. Que
;
M. H. Chen
;
J. C. Sun
;
T. B. Liu
;
H. L. Liu
;
M. Liu
;
A. Q. Yang
;
P. Yang
;
Y. L. Wang
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  |  
浏览/下载:44/0
  |  
提交时间:2012/06/06
Cucurmosin
chronic myeloid leukemia
k562 cells
apoptosis
ribosome-inactivating protein
cucurbita-moschata
oxidative stress
cancer cells
degradation
activation
sarcocarp
pathway
acid
Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1
期刊论文
Bmc Structural Biology, 2011, 卷号: 11
C. Yuan
;
L. Q. Chen
;
E. J. Meehan
;
N. Daly
;
D. J. Craik
;
M. D. Huang
;
J. C. Ngo
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  |  
浏览/下载:28/0
  |  
提交时间:2012/06/06
transmembrane serine-protease
hepatocyte growth-factor
factor
activator inhibitor-1
autosomal recessive ichthyosis
cation-pi
interactions
expression
mutation
design
cancer
potent
Substituted zinc phthalocyanine as an antimicrobial photosensitizer for periodontitis treatment
期刊论文
Journal of Porphyrins and Phthalocyanines, 2011, 卷号: 15, 期号: 4, 页码: 293-299
J. C. Chen
;
Z. Chen
;
Y. Q. Zheng
;
S. Y. Zhou
;
J. D. Wang
;
N. S. Chen
;
J. L. Huang
;
F. H. Yan
;
M. D. Huang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2012/06/06
Porphyromonas gingivalis
periodontitis
photodynamic therapy
antimicrobial activity
zinc phthalocyanine-polylysine conjugate
photodynamic therapy
beagle dog
in-vitro
bacteria
disease
model
cancer
Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1
期刊论文
Journal of Biological Chemistry, 2011, 卷号: 286, 期号: 9, 页码: 7027-7032
Z. H. Lin
;
L. G. Jiang
;
C. Yuan
;
J. K. Jensen
;
X. Zhang
;
Z. P. Luo
;
B. C. Furie
;
B. Furie
;
P. A.
;
reasen
;
M. D. Huang
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2012/06/06
breast-cancer
crystal-structure
reactive-center
tumor-markers
serpin
complex
target
polymerization
fibrinolysis
vitronectin
Pentalysine beta-Carbonylphthalocyanine Zinc: An Effective Tumor-Targeting Photosensitizer for Photodynamic Therapy
期刊论文
Chemmedchem, 2010, 卷号: 5, 期号: 6, 页码: 890-898
Z. Chen, S. Y. Zhou, J. C. Chen, Y. C. Deng, Z. P. Luo, H. W. Chen, M. R. Hamblin and M. D. Huang
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  |  
浏览/下载:13/0
  |  
提交时间:2012/11/02
cancer
cytotoxicity
pharmacokinetics
photodynamic therapy
synthesis
disulfonated aluminum phthalocyanine
mitochondria-dependent apoptosis
intensity laser therapy
chinese-hamster cells
biological-activities
photochemical properties
different mechanisms
cancer
series
photofrin
Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition
期刊论文
Combinatorial Chemistry & High Throughput Screening, 2009, 卷号: 12, 期号: 10, 页码: 961-967
Z. Chen, L. Lin, Q. Huai and M. D. Huang
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  |  
浏览/下载:80/0
  |  
提交时间:2012/11/06
plasminogen-activator-receptor
amino-terminal fragment
binding site
tumor-growth
cancer-patients
ovarian-cancer
peptide antagonists
cell-line
in-vitro
invasion
Applications of Peptide Conjugated Photosensitizers in Photodynamic Therapy
期刊论文
Progress in Biochemistry and Biophysics, 2009, 卷号: 36, 期号: 9, 页码: 1106-1113
H. W. Chen, J. C. Chen, N. S. Chen, J. L. Huang, J. D. Wang and M. D. Huang
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  |  
浏览/下载:17/0
  |  
提交时间:2012/11/06
photodynamic therapy
photosensitizer
cancer
targeted
peptide
chlorin-type photosensitizer
in-vitro
choroidal neovascularization
protoporphyrin-ix
tumors
cells
neuropilin-1
phthalocyanines
angiogenesis
receptors
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