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科研机构
上海药物研究所 [63]
内容类型
期刊论文 [63]
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2021 [2]
2020 [3]
2019 [3]
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Chemistry [5]
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内容类型:期刊论文
专题:上海药物研究所
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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Dai, Meng-di
;
Wang, Yue-liang
;
Fan, Jun
;
Dai, Yang
;
Ji, Yin-chun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
receptor tyrosine kinase
FGFR inhibitor
DW14383
antitumor activity
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors
期刊论文
CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+
作者:
Li, Huiping
;
Liu, Rongrui
;
Shao, Bin
;
Ran, Ran
;
Song, Guohong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
Phase I
PARP inhibitor (fluzoparib)
solid tumor
pharmacokinetics
safety
antitumor activity
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Chen, Xiang-ling
;
Liu, Peng
;
Zhu, Wei-liang
;
Lou, Li-guang
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/01
DCZ5248
Hsp90
autophagy
lysosomal function
antitumor activity
colon cancer
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
期刊论文
CHEMISTRYOPEN, 2019, 卷号: 8, 期号: 3, 页码: 344-353
作者:
Liu, Peng
;
Chen, Xiangling
;
Zhu, Jianming
;
Li, Bo
;
Chen, Zhaoqiang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials
期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 3, 页码: 1064-1075
作者:
Wang, Lei
;
Yang, Changyong
;
Xie, Chengying
;
Jiang, Jiahua
;
Gao, Mingzhao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
antitumor activity
fluzoparib
pharmacokinetics
poly(ADP-ribose) polymerase
toxicity
trailbasedgenedeliveryandtherapeuticstrategies
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1373
作者:
Zhong Huihai
;
Wang Huiyuan
;
Li Jian
;
Huang Yongzhuo
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
APOPTOSIS-INDUCING LIGAND
MESENCHYMAL STEM-CELLS
PROSTATE-CANCER CELLS
DEATH RECEPTOR 5
CO-DELIVERY
IN-VIVO
MEDIATED APOPTOSIS
ANTITUMOR-ACTIVITY
TUMORICIDAL ACTIVITY
PROTEIN EXPRESSION
TRAIL
gene delivery
gene therapy
DNA
drug delivery systems
non-viral vectors
cancer therapy
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153
作者:
Zha, Chuantao
;
Deng, Wenjia
;
Fu, Yan
;
Tang, Shuai
;
Lan, Xiaojing
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2019/01/08
Structure-based drug design
Selective CDK4/6 inhibitors
Structure-activity relationship study
In vivo antitumor activity
Studies on methyl xestopongoate analogues:design,synthesis and antitumor activities
期刊论文
Journal of China Pharmaceutical University, 2018, 卷号: 49, 期号: 4, 页码: 413-421
作者:
Sun Dongyu
;
Gong Jingxu
;
Li Xuwen
;
Han Guanying
;
Guo Yuewei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Methyl Xestospongoate
Methyl Xestospongoate
polyacethlene
analogues
synthesis
antitumor activity
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