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科研机构
上海药物研究所 [16]
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期刊论文 [15]
会议论文 [1]
发表日期
2020 [3]
2019 [2]
2018 [2]
2017 [1]
2015 [1]
2014 [2]
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Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
收藏
  |  
浏览/下载:237/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
期刊论文
ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596
作者:
Dou, Hui-Xia
;
Wang, Ting
;
Su, Hai-Xia
;
Gao, Ding-Ding
;
Xu, Ye-Chun
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
eFABP4
Adipocyte
Differentiation
Lipolysis
Inflammation
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 (vol 154, pg 44, 2018)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 235-236
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
FABP4 inhibitors
FABP3 sparing
Structure-based design strategy
X-ray crystallography
Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 177-183
作者:
Chen, Yu-ting
;
Chen, Wu-yan
;
Huang, Xiao-tian
;
Xu, Ye-chun
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
iron
neurons
amyloid precursor protein
sAPP alpha
beta-amyloid
beta-secretase
Alzheimer's disease
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
ERK/GSK3β signaling is involved in atractylenolide I-induced apoptosis and cell cycle arrest in melanoma cells
期刊论文
Oncology reports, 2015, 卷号: 34, 期号: 3, 页码: 1543-8
作者:
Ye, Yan
;
Chao, Xiao-Juan
;
Wu, Jin-Feng
;
Cheng, Brian Chi-Yan
;
Su, Tao
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Xanthones from Swertia mussotii as Multitarget-Directed Antidiabetic Agents
期刊论文
CHEMMEDCHEM, 2014, 卷号: 9, 期号: 7, 页码: 1374-1377
作者:
Zheng, Huan-Huan
;
Luo, Cui-Ting
;
Chen, Heru
;
Lin, Juan-Na
;
Ye, Chun-Ling
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
aldose reductases
antioxidants
diabetes
alpha-glucosidases
multitarget inhibitors
xanthones
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