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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
发表日期
2021 [1]
2020 [1]
2018 [4]
2017 [3]
2016 [1]
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Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents
期刊论文
BIOSCIENCE TRENDS, 2021, 卷号: 15, 期号: 4, 页码: 231-239
作者:
Wang, Wenwen
;
Zhang, Zijia
;
Deng, Yanping
;
Yang, Zhixin
;
Hou, Jinjun
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Neuroinflammation
Shenqi Fuzheng Injection (SFI)
Arginase 1 (Arg1)
Transforming growth factor beta-1 (Tgfb1)
microglia
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening
期刊论文
CHEMICAL SCIENCE, 2018, 卷号: 9, 期号: 12, 页码: 3192-3199
作者:
Qin, Shanshan
;
Meng, Mengmeng
;
Yang, Dehua
;
Bai, Wenwen
;
Lu, Yan
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 3, 页码: 233-237
作者:
Ni, Shuaishuai
;
Li, Baoli
;
Chen, Feifei
;
Wei, Hanwen
;
Mao, Fei
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Virulence factor
pigment
multidrug resistant MRSA
CrtN inhibitor
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 19, 页码: 8145-8159
作者:
Ni, Shuaishuai
;
Wei, Hanwen
;
Li, Baoli
;
Chen, Feifei
;
Liu, Yifu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 830-834
作者:
Lu, Dong
;
Yan, Juan
;
Wang, Lang
;
Liu, Hongchun
;
Zeng, Limin
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Dual c-Met/HDAC inhibitor
hybrid
designed multiple ligand (DML)
Hybrid quadrupole-orbitrap mass spectrometry analysis with accurate-mass database and parallel reaction monitoring for high-throughput screening and quantification of multi-xenobiotics in honey
期刊论文
Journal of chromatography. A, 2016, 卷号: 1429, 页码: 119-26
作者:
Li, Yi
;
Zhang, Jinzhen
;
Jin, Yue
;
Wang, Lin
;
Zhao, Wen
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
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