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科研机构
上海药物研究所 [78]
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期刊论文 [76]
会议论文 [2]
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2021 [4]
2018 [2]
2017 [6]
2016 [4]
2015 [11]
2014 [4]
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Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2021, 页码: 11
作者:
Xiong, Zhaoping
;
Cheng, Ziqiang
;
Lin, Xinyuan
;
Xu, Chi
;
Liu, Xiaohong
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  |  
浏览/下载:45/0
  |  
提交时间:2021/11/04
federated learning
drug discovery
FedAMP
Non-IID data
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
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  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development
期刊论文
PLANT JOURNAL, 2021, 页码: 10
作者:
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  |  
浏览/下载:43/0
  |  
提交时间:2021/08/17
Phytohormone
GR24
2NOD
Signaling Pathway
Plant growth regulator
Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory
期刊论文
MOLECULAR PSYCHIATRY, 2021, 页码: 19
作者:
Wang, Yu-Jun
;
Yu, Chuan
;
Wu, Wei-Wei
;
Ju, Yun-Yue
;
Liu, Yao
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  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
Transport mechanism of lipid covered saquinavir pure drug nanoparticles in intestinal epithelium
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2018, 卷号: 269, 页码: 159-170
作者:
Xia, Dengning
;
He, Yuan
;
Li, Qiuxia
;
Hu, Cunde
;
Huang, Wei
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Surface modification
Phospholipid bilayer
Nanodrug
Endocytosis
Transcytosis
P-type glycoprotein substrate
Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal
期刊论文
EMBO MOLECULAR MEDICINE, 2017, 卷号: 9, 期号: 11, 页码: 1521-1536
作者:
Zhang, Lei
;
Kibaly, Cherkaouia
;
Wang, Yu-Jun
;
Xu, Chi
;
Song, Kyu Young
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
lentivirus injection
locus coeruleus
naloxone-precipitated opiate withdrawal
opiate addiction
Src-mediated phosphorylation of MOR at Tyr(336)
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression
期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8
作者:
Ju, Junyi
;
Chen, Aiping
;
Deng, Yexuan
;
Liu, Ming
;
Wang, Ying
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浏览/下载:44/0
  |  
提交时间:2019/01/08
Self-Assembled Core-Shell-Type Lipid-Polymer Hybrid Nanoparticles: Intracellular Trafficking and Relevance for Oral Absorption
期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 106, 期号: 10, 页码: 3120-3130
作者:
Li, Qiuxia
;
Xia, Dengning
;
Tao, Jinsong
;
Shen, Aijun
;
He, Yuan
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  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
endocytosis
drug transport
oral absorption
poly(lactic-co-glycolic acid) nanoparticles
saquinavir
Heteromers of ae opioid and dopamine D1 receptorsmodulate opioid-induced locomotor sensitization in a dopamine-independent manner
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2017, 卷号: 174, 期号: 17, 页码: 2842-2861
作者:
Tao, Yi-Min
;
Yu, Chuan
;
Wang, Wei-Sheng
;
Hou, Yuan-Yuan
;
Xu, Xue-Jun
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  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
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