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科研机构
上海药物研究所 [24]
内容类型
期刊论文 [24]
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2021 [3]
2020 [2]
2019 [1]
2018 [3]
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2015 [2]
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FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12
作者:
Wang, Lan
;
Zhao, Danfeng
;
Wang, Huan
;
Wang, Lele
;
Liu, Xiaohui
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/12/01
Inflammation
Microglia
LPS
RNA-seq
JAK
STAT signaling pathway
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution
期刊论文
ADVANCED SCIENCE, 2021, 页码: 14
作者:
Sun, Xian
;
Zhang, Xiaochuan
;
Ren, Xiaohong
;
Sun, Hongyu
;
Wu, Li
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  |  
浏览/下载:81/0
  |  
提交时间:2021/05/24
dry powder inhalation
fluorescence‐
micro optical sectioning tomography
inhaled materials
pulmonary drug delivery
three‐
dimensional rendering
Structure of SARS-CoV-2 main protease in the apo state
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020, 页码: 4
作者:
Zhou, Xuelan
;
Zhong, Fanglin
;
Lin, Cheng
;
Hu, Xiaohui
;
Zhang, Yan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 1, 页码: 119
作者:
Sun Di
;
Guo Shiyan
;
Yang Li
;
Wang Yaru
;
Wei Xiaohui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2020/07/01
Diabetic ulcer
ordered recovery
scarless wound healing
20 (S)-protopanaxadiol
nanostructured lipid carrier
silicone elastomer
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
作者:
Tao, Hongru
;
Wang, Jun
;
Lu, Wenchao
;
Zhang, Rukang
;
Xie, Yiqian
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Andrographolide Sulfonate Attenuates Acute Lung Injury by Reducing Expression of Myeloperoxidase and Neutrophil-Derived Proteases in Mice
期刊论文
FRONTIERS IN PHYSIOLOGY, 2018, 卷号: 9
作者:
Gao, Fei
;
Liu, Xing
;
Shen, Ziying
;
Jia, Xiaohui
;
He, Han
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  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
andrographolide sulfonate
acute lung injury
iTRAQ
quantitative proteomics
immunohistochemistry
Development and validation of a highly sensitive LC-MS/MS method for determination of brain active agent dianhydrogalactitol in mouse plasma and tissues: Application to a pharmacokinetic study
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 卷号: 1087, 页码: 90-97
作者:
Sun, Lihan
;
Wu, Huajing
;
Ren, Lianjie
;
Cong, Jiaojiao
;
Qin, Xiaohui
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
1,2:5,6-dianhydrogalactitol
Derivatization
LC-MS/MS
Plasma
Tissue distribution
proteomicsanalysisrevealsapotentialnewtargetproteinforthelipidloweringeffectofberberine8998
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 9, 页码: 1473
作者:
u Chengyin
;
Liu Gangyi
;
Liu Xiaohui
;
Gui Yuzhou
;
Liu Haiming
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
DISEASE
ATHEROSCLEROSIS
IDENTIFICATION
CHALLENGES
EFFICACY
RECEPTOR
berberine
berberine8998
proteomics
lipid-lowering
cholesterol
triglycerides
LDL-C
fatty acid metabolism
hypercholesterolemia
obesity
Development and application of component-based Chinese medicine theory
期刊论文
China Journal of Chinese Materia Medica, 2017, 卷号: 42, 期号: 21, 页码: 4054-4058
作者:
Zhang Junhua
;
Fan Guanwei
;
Zhang Han
;
Fan Xiaohui
;
Wang Yi
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
component-based Chinese medicine
compatibility of Chinese medicinal prescription
efficacy-oriented compatibility
modernization of Chinese medicine
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