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科研机构
上海药物研究所 [30]
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期刊论文 [29]
会议论文 [1]
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2021 [1]
2020 [2]
2019 [1]
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Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Introducing "Future of Biochemistry 2020: The Asia-Pacific Issue"
期刊论文
BIOCHEMISTRY, 2020, 卷号: 59, 期号: 1, 页码: 1-7
作者:
Ananthanarayanan, Vaishnavi
;
Chattopadhyay, Kausik
;
Chen, Lei
;
Cheng, Liang
;
Edgington-Mitchell, Laura
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  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 94, 页码: 8
作者:
Cui, Wan-Xiang
;
Yang, Min
;
Li, Heng
;
Li, Song-Wei
;
Yao, Li-Gong
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Norditerpenoids
Sinularia
Absolute configuration
Immunosuppressive activity
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 13
作者:
Han, Yamei
;
Hu, Zhimin
;
Cui, Aoyuan
;
Liu, Zhengshuai
;
Ma, Fengguang
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  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
期刊论文
Cell reports, 2018, 卷号: 25, 期号: 13, 页码: 3582-3590.e4
作者:
Zhang, Jin-Bao
;
Chang, Shenghai
;
Xu, Pan
;
Miao, Miao
;
Wu, Hangjun
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  |  
浏览/下载:118/0
  |  
提交时间:2019/01/08
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
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  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 56-68
作者:
Yang, Li-yun
;
Liu, Xiao-fang
;
Yang, Yang
;
Yang, Lin-lin
;
Liu, Kai-wen
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
CD97
adhesion GPCR
auto-proteolysis
HeLa cell attachment
N-glycosylation
Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 11, 页码: 1516
作者:
Wu Xishan
;
Wang Rui
;
Xing Yanli
;
Xue Xiaoqian
;
Zhang Yan
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/12/24
GAMMA-T
ORPHAN RECEPTORS
CELL-DIFFERENTIATION
LIGAND
IDENTIFICATION
MODULATORS
DERIVATIVES
PROTEIN
INHIBITORS
DOCKING
nuclear receptor
RORc
inverse agonist
SAR
structure-based optimization
autoimmune disease
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
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