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科研机构
上海药物研究所 [124]
内容类型
期刊论文 [123]
专利 [1]
发表日期
2021 [11]
2020 [10]
2019 [4]
2018 [7]
2017 [10]
2016 [8]
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New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 28-38
作者:
Lin, Na
;
Li, Heng
;
Wang, Jian-Rong
;
Tang, Wei
;
Zheng, Ming-Yue
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/04
Sinularia nanolobata
Cembranoids
X-ray diffraction
Configuration determination
Natural products
Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 11, 页码: 2444-2452
作者:
Wang, Jiang
;
Yang, Dehua
;
Cheng, Xi
;
Yang, Linlin
;
Wang, Zhaohui
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/04
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 11
作者:
Ma, Shanshan
;
Chen, Yan
;
Dai, Antao
;
Yin, Wanchao
;
Guo, Jia
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/11/04
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 32, 页码: 8
作者:
Wang, Xi
;
Cheng, Xi
;
Zhao, Lihua
;
Wang, Yuzhe
;
Ye, Chenyu
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/11/04
parathyroid hormone receptor 2
cryo-electron microscopy
G protein-coupled receptor
ligand recognition
syndromic short stature
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
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  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
期刊论文
CELL RESEARCH, 2021, 页码: 3
作者:
Zhou, Fulai
;
Ye, Chenyu
;
Ma, Xiaomin
;
Yin, Wanchao
;
Croll, Tristan I.
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
Discovery of New alpha-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
期刊论文
FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 9
作者:
Liu, Shan-Kui
;
Hao, Haifang
;
Bian, Yuan
;
Ge, Yong-Xi
;
Lu, Shengyuan
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/05/24
α
-glycosidase
virtual screening
cytotoxicity
type 2 diabetes
molecular docking
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