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上海药物研究所 [12]
山东大学 [8]
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期刊论文 [45]
发表日期
2013 [45]
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Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998
作者:
Zhang, Xu
;
Peng, Ting
;
Ji, Xun
;
Li, Jian
;
Tong, Linjiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
EGFR inhibitor
EGFR T790M/L858R
Binding mode
Irreversible EGFR inhibitor
Transcriptome Profiling Analysis on Whole Bodies of Microbial Challenged Eriocheir sinensis Larvae for Immune Gene Identification and SNP Development
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 12, 页码: e82156
作者:
Cui, Zhaoxia
;
Li, Xihong
;
Liu, Yuan
;
Song, Chengwen
;
Hui, Min
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2014/07/17
Insight into the Structural Requirements of Benzimidazole Derivatives as Interleukin-2 Inducible T-cell Kinase Inhibitors by Computational Explorations
期刊论文
international journal of quantum chemistry, 2013, 卷号: 113, 期号: 21, 页码: 2385-2396
作者:
Wang, Jinghui
;
Li, Feng
;
Li, Yan
;
Yang, Yinfeng
;
Wang, Bin
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  |  
浏览/下载:17/0
  |  
提交时间:2015/11/09
3D-QSAR
ITK inhibitors
comparative molecular field analysis
comparative molecular similarity indices analysis
molecular dynamics
docking
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1475-1483
作者:
Yu, Zhe
;
Ma, Yu-chi
;
Ai, Jing
;
Chen, Dan-qi
;
Zhao, Dong-mei
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
receptor tyrosine kinase
type I c-Met inhibitor
cancer
quantum chemistry
protein-ligand interaction
symmetry-adapted perturbation theory (SAPT)
Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 21, 页码: 6804-6820
作者:
Zhang, Dengyou
;
Zhang, Xiaowei
;
Ai, Jing
;
Zhai, Yun
;
Liang, Zhongjie
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Receptor tyrosine kinase
c-Met
2-Amino-5-aryl-3-benzylthiopyridine
Phase I study of the safety, pharmacokinetics and antitumor activity of famitinib
期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 5, 页码: 1043-1053
作者:
Zhou, Aiping
;
Zhang, Wen
;
Chang, Chunxiao
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Famitinib
Phase I trial
Safety
Pharmacokinetics
Antitumor activity
RON confers lapatinib resistance in HER2-positive breast cancer cells
期刊论文
CANCER LETTERS, 2013, 卷号: 340, 期号: 1, 页码: 43-50
作者:
Wang, Quanren
;
Quan, Haitian
;
Zhao, Jie
;
Xie, Chengying
;
Wang, Lei
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  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
RON
Lapatinib resistance
HER2
HER2-targeted agents
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 4, 期号: 10, 页码: 974-978
作者:
Wu, Jianwei
;
Chen, Wenteng
;
Xia, Guangxin
;
Zhang, Jing
;
Shao, Jiaan
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  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Anticancer
kinase inhibitor
EGFR
conformationally constrained
Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 卷号: 13, 期号: 17, 页码: 2116-2126
作者:
Liu, Yanjuan
;
Liu, Junxi
;
Di, Duolong
;
Li, Min
;
Fen, Yan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/11/15
Natural product
Aporphinoid alkaloids
Chemical structure
Anticancer activity
Apoptosis
SARs
Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma
期刊论文
CANCER LETTERS, 2013, 卷号: 337, 期号: 1, 页码: 96-106
作者:
Wang, YP
;
Huang, LY
;
Sun, WM
;
Zhang, ZZ
;
Fang, JZ
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  |  
浏览/下载:3/0
  |  
提交时间:2015/12/22
IRTKS
Hepatocellular carcinoma
Proliferation
EGFR/ERK signalling
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