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CORC

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Understanding Gene Therapy in Acute Respiratory Distress Syndrome 期刊论文
CURRENT GENE THERAPY, 2019, 卷号: 19, 期号: 2
作者:  Zhang, Xue-Peng;  Zhang, Wei-Tao;  Qiu, Yue;  Ju, Min-Jie;  Tu, Guo-Wei
收藏  |  浏览/下载：21/0  |  提交时间：2019/12/05
Peptide GE11-Polyethylene Glycol-Polyethylenimine for targeted gene delivery in laryngeal cancer 期刊论文
MEDICAL ONCOLOGY, 2015, 卷号: 32, 期号: 7
作者:  Ren, Henglei;  Zhou, Liang;  Liu, Min;  Lu, Weiyue;  Gao, Chunli
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/19
Efficient gene delivery to human umbilical cord mesenchymal stem cells by cationized Porphyra yezoensis polysaccharide nanoparticles 期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 卷号: 10, 页码: 7097-7107
作者:  Yu, Qingtong[1];  Cao, Jin[2];  Chen, Baoding[3];  Deng, Wenwen[4];  Cao, Xia[5]
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/24
Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer 期刊论文
PEPTIDES, 2013, 卷号: 46, 页码: 33-39
作者:  Zhang, W;  Song, JJ;  Liang, RR;  Zheng, X;  Chen, JB
收藏  |  浏览/下载：3/0  |  提交时间：2016/03/29
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
Gadolinium embedded iron oxide nanoclusters as T-1-T-2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery 期刊论文
http://dx.doi.org/10.1039/c3nr02797j, 2013
Wang, Xiaoyong; Zhou, Zijian; Wang, Zhiyong; Xue, Yunxin; Zeng, Yun; Gao, Jinhao; Zhu, Lei; Zhang, Xianzhong; Liu, Gang; Chen, Xiaoyuan; 高锦豪; 张现忠; 刘刚; 陈小元
收藏  |  浏览/下载：5/0  |  提交时间：2015/07/22
Double-targeted and double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for prostate cancer 期刊论文
Molecular Carcinogenesis, 2013, 卷号: Vol.52 No.3, 页码: 237-246
作者:  Yue Chen;  Gang Wang;  Deling Kong;  Zhihong Zhang;  Kuo Yang
收藏  |  浏览/下载：3/0  |  提交时间：2019/03/26
Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer 期刊论文
International Journal of Nanomedicine, 2012, 卷号: 7
作者:  Chen, Yinting[0];  Wang, Weiwei[1];  Lian, Guoda[2];  Qian, Chenchen[3];  Wang, Lingyun[4]
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/04
Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer 期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 卷号: 7
作者:  Chen, Yinting;  Wang, Weiwei;  Lian, Guoda;  Qian, Chenchen;  Wang, Lingyun
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/04
Temperature-tuned DNA condensation and gene transfection by PEI-g-(PMEO2MA-b-PHEMA) copolymer-based nonviral vectors 期刊论文
Biomaterials, 2010, 卷号: Vol.31 No.1, 页码: 144-155
作者:  Yang, J.a;  Zhang, P.a;  Tang, L.a;  Sun, P.a;  Liu, W.a
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/21

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