×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [11]
中国医学科学院 北京... [2]
北京大学 [1]
中国科学院大学 [1]
山东大学 [1]
华中师范大学 [1]
更多...
内容类型
期刊论文 [21]
发表日期
2021 [1]
2019 [4]
2018 [3]
2017 [2]
2016 [7]
2015 [1]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共21条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020)
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842
作者:
Wu, Jingwei
;
Zhang, Huan
;
Zhao, Guilong
;
Wang, Runling
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2021/08/17
SHP2 inhibitor
PTPN11 gene
allosteric
cancer
combination therapy
clinical trial
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 21, 页码: 8653-8663
作者:
Li, Kangshuai
;
Hou, Xuben
;
Li, Ruirui
;
Bi, Wenxiang
;
Yang, Fan
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2019/12/11
allosteric regulation
enzyme inhibitor
enzyme
inhibitor
nuclear
magnetic resonance (NMR)
autoimmunity
lymphoid-specific tyrosine
phosphatase (LYP)
protein-tyrosine phosphatase nonreceptor type 22
(PTPN22)
tyrosine phosphatase inhibitor
WPD-loop
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:
Shan Hui
;
Yao Sheng
;
Ye Yang
;
Yu Qiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2β
16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
中国药理学报:英文版, 2019, 卷号: 40.0, 期号: 012, 页码: 1578
作者:
Hui Shan
;
Sheng Yao
;
Yang Ye
;
Qiang Yu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/12/24
JAK/STAT
3-deoxy-2β,16-dihydroxynagilactone
E
tyrosine
kinase
inhibitor
allosteric
inhibitor
cancer
Exploring molecular mechanism of allosteric inhibitor to relieve drug resistance of multiple mutations in HIV-1 protease by enhanced conformational sampling
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, 卷号: 86, 期号: 12, 页码: 1294-1305
作者:
Chen, Jianzhong
;
Peng, Cheng
;
Wang, Jinan
;
Zhu, Weiliang
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/01/08
allosteric inhibitor
HIV-1 protease
MM-GBSA
normal mode analysis
REMD
Structure Optimization and Structure-Activity Relationship Study of a Kind of Type II FAK Inhibitors with N-Phenylpyrazole Ureas
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 11
作者:
Gong Chaochao
;
Tan Hanyi
;
Zhang Qian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
focal adhesion kinase
allosteric hydrophobic pocket
type II inhibitor
N-phenylpyrazole
structure optimization
Inhibition of P-Glycoprotein Mediated Efflux in Caco-2 Cells by Phytic Acid
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 卷号: 66, 期号: 4
作者:
Li, Lujia
;
Fu, Qingxue
;
Xia, Mengxin
;
Xin, Lei
;
Shen, Hongyi
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
allosteric modulation
efflux
P-glycoprotein inhibitor
phytic acid
rhodamine 123
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1051-1063
作者:
Zhang, Feng-Hua
;
Debnath, Bikash
;
Xu, Zhong-Liang
;
Yang, Liu-Meng
;
Song, Li-Rui
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
HIV-1 integrase
Allosteric inhibitor
LEDGF/p75
Dimerization
3-Hydroxypicolinamide
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:
Zhang FH
;
Debnath B
;
Zheng YT
;
Neamati N[*]
;
Long YQ[*]
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2016/11/07
3-Hydroxypicolinamide
Allosteric inhibitor
Dimerization
HIV-1 integrase
LEDGF/p75
©版权所有 ©2017 CSpace - Powered by
CSpace