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清华大学 [10]
复旦大学上海医学院 [8]
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武汉大学 [7]
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Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Integrated Genomic Analysis Revealed Associated Genes for Alzheimer's Disease in APOE4 Non-Carriers
期刊论文
CURRENT ALZHEIMER RESEARCH, 2019, 卷号: 16, 期号: 8
作者:
Jiang, Shan
;
Zhang, Chun-Yun
;
Tang, Ling
;
Zho, Lan-Xue
;
Chen, Hong-Zhuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
late-onset Alzheimer's disease
APOE4
APOE4 non-carriers
integrated genomic analysis
protein kinase C-gamma
tau phosphorylation
Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3 beta signaling pathway in Alzheimer's disease
期刊论文
LIFE SCIENCES, 2019, 卷号: 217, 页码: 16-24
作者:
Yao, Yingjia
;
Wang, Yameng
;
Kong, Liang
;
Chen, Yuqing
;
Yang, Jingxian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/02
Alzheimer's disease
Phosphorylated tau protein
Apoptosis
PI3K
Osthole
Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2019, 卷号: 68, 期号: 1
作者:
Guo, Jing
;
Xu, Cheng
;
Ni, Shaozhou
;
Zhang, Shujuan
;
Li, Qihang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Alzheimer's disease
hyperhomocysteinemia
methylated/de-methylated protein phosphatase-2A
phosphorylated tau
retina
IMM-H004 reduced okadaic acid-induced neurotoxicity by inhibiting Tau pathology in vitro and in vivo
期刊论文
2019
作者:
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Alzheimer’s disease
IMM-H004
Tau protein
neuroprotection
okadaic acid
MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB
期刊论文
2019, 卷号: 10, 页码: 806
作者:
Wang, Linlin
;
Liu, Jianghong
;
Wang, Qian
;
Jiang, Hailun
;
Zeng, Li
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/01/03
Alzheimer's disease
miR-200a-3p
BACE1
PRKACB
tau protein
apoptosis
IMM-H004 reduced okadaic acid-induced neurotoxicity by inhibiting Tau pathology in vitro and in vivo.
期刊论文
Neurotoxicology, 2019, 卷号: 75, 页码: 221-232
作者:
Wang, Yingying
;
Song, Xiuyun
;
Liu, Dandan
;
Lou, Yu-Xia
;
Luo, Piao
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/27
*Alzheimer's disease
*IMM-H004
*Neuroprotection
*Okadaic acid
*Tau protein
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia
期刊论文
ALZHEIMERS RESEARCH & THERAPY, 2018, 卷号: 10, 页码: 15
作者:
Ji, Mei
;
Xie, Xi-xiu
;
Liu, Dong-qun
;
Yu, Xiao-lin
;
Zhang, Yue
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2018/07/17
Alzheimer's Disease
Frontotemporal Dementia
Hepatitis b Core Protein
Truncated Tau
Neurofibrillary Tangles
Virus-like Particles (Vlps)
Vaccine
Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats
期刊论文
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 卷号: 22, 期号: 11
作者:
Yang, T. -W.
;
Zheng, H. -B.
;
Fu, Y. -T.
;
Wang, G.
;
Sun, L. -H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Propofol
Anesthesia
Cognitive function
Tau protein
Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 45
作者:
Weismiller, Hilary A.
;
Murphy, Rachel
;
Wei, Guanghong
;
Ma, Buyong
;
Nussinov, Ruth
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
Tau protein (Tau)
amyloid
conformational change
Alzheimer disease
tauopathy
electron paramagnetic resonance (EPR)
fibril
protein aggregation
prion
protein structure
seeding barrier
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