CORC

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CORC

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Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199
作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan
收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04
Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 9
作者:  Wang, Yue;  Guo, Shimeng;  Zhuang, Youwen;  Yun, Ying;  Xu, Peiyu
收藏  |  浏览/下载：42/0  |  提交时间：2021/11/04
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:  Wang, Congcong;  Zhang, Yu-Fang;  Guo, Shimeng;  Zhao, Quan;  Zeng, Yanping
收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52 期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 12, 页码: 3275-3284
作者:  Ma, Mengna;  Guo, Shimeng;  Lin, Xi;  Li, Shanshan;  Wu, Yiran
收藏  |  浏览/下载：16/0  |  提交时间：2021/05/24
Structural basis of GPBAR activation and bile acid recognition 期刊论文
NATURE, 2020, 页码: 29
作者:  Yang, Fan;  Mao, Chunyou;  Guo, Lulu;  Lin, Jingyu;  Ming, Qianqian
收藏  |  浏览/下载：45/0  |  提交时间：2020/12/24
Structural basis of ligand recognition and self-activation of orphan GPR52 期刊论文
NATURE, 2020, 页码: 21
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu
收藏  |  浏览/下载：167/0  |  提交时间：2020/07/01
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:  Kong, Deyu;  Guo, Shimeng;  Yang, Yushe;  Guo, Bin;  Xie, Xin
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia
收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes 期刊论文
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:  Song, Haikun;  Li, Hexuan;  Guo, Shimeng;  Pan, Yuyin;  Fu, Yuhua
收藏  |  浏览/下载：52/0  |  提交时间：2019/01/08
The Ross Sea Dipole - temperature, snow accumulation and sea ice variability in the Ross Sea region, Antarctica, over the past 2700 years 期刊论文
CLIMATE OF THE PAST, 2018, 卷号: 14, 期号: 2, 页码: 193-214
作者:  Bertler, Nancy A. N.;  Conway, Howard;  Dahl-Jensen, Dorthe;  Emanuelsson, Daniel B.;  Winstrup, Mai
收藏  |  浏览/下载：79/0  |  提交时间：2019/10/09

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