CORC

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CORC

浏览/检索结果: 共17条，第1-10条 帮助

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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:  He, Qian;  Wei, Yuanyuan;  Liu, Xiao;  Ye, Rongrong;  Kong, Linghui
收藏  |  浏览/下载：88/0  |  提交时间：2021/11/04
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li
收藏  |  浏览/下载：114/0  |  提交时间：2021/05/24
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载：93/0  |  提交时间：2020/07/01
Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of beta-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease 期刊论文
FRONTIERS IN AGING NEUROSCIENCE, 2019, 卷号: 11
作者:  Wang, Yu;  Xia, Jia;  Shen, Mengjun;  Zhou, Yifan;  Wu, Zhe
收藏  |  浏览/下载：21/0  |  提交时间：2019/12/05
Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice 期刊论文
TRANSLATIONAL NEURODEGENERATION, 2018, 卷号: 7
作者:  Shi, Yuhuan;  Huang, Wanying;  Wang, Yu;  Zhang, Rui;  Hou, Lina
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis 期刊论文
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 卷号: 32, 期号: 1
作者:  Xie, Qiong;  Zheng, Zhaoxi;  Shao, Biyun;  Fu, Wei;  Xia, Zheng
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/05
Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC-MS/MS: Application to pharmacokinetic study after intravenous and subcutaneous administration 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 卷号: 96
作者:  Xie, Ying;  Jiang, Pan;  Ge, Xinxing;  Wang, Hao;  Shao, Biyun
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19
Determination of Meserine, a new candidate for Alzheimer's disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study 期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 卷号: 406, 期号: 14
作者:  Zheng, Zhaoxi;  Tang, Yabin;  Lv, Haoyu;  Xu, Jianrong;  Zhao, Hengyi
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19
Dual Binding Site Acetylcholinesterase Inhibitors 期刊论文
PROGRESS IN CHEMISTRY, 2013, 卷号: 25, 期号: 11
作者:  Zheng Wei;  Xie Qiong;  Chen Liangkang;  Chen Jianxing;  Qiu Zhuibai
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/19
Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 卷号: 264, 期号: 1
作者:  Zheng, Wei;  Li, Juan;  Qiu, Zhuibai;  Xia, Zheng;  Li, Wei
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19

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