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浏览/检索结果: 共2条，第1-2条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Novel 2-arylthiopropanoyl-CoA inhibitors of alpha-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents 期刊论文 BIOORGANIC CHEMISTRY, 2019, 卷号: 92 作者:  Yevglevskis, Maksims;  Nathubhai, Amit;  Wadda, Katty;  Lee, Guat L.;  Al-Rawi, Suzanne 收藏  |  浏览/下载：31/0  |  提交时间：2019/12/11 alpha-Methylacyl-CoA racemase (AMACR, P504S)  Branched-chain fatty acid  metabolism  Castrate-resistant prostate cancer (CRPC)  Drug  lipophilicity  Enzyme inhibitors  Ibuprofen  Mixed competitive  inhibition  Rational drug design  Structure-activity relationships   Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13, 页码: 3013-3032 作者:  Kumpan, Katerina;  Nathubhai, Amit;  Zhang, Chenlu;  Wood, Pauline J.;  Lloyd, Matthew D. 收藏  |  浏览/下载：1/0  |  提交时间：2019/12/17 Tankyrase  TNKS  Naphthyridinone  7-Aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one  Crystal  structure