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科研机构
上海大学 [13]
内容类型
期刊论文 [13]
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2019 [2]
2018 [2]
2017 [1]
2016 [2]
2015 [2]
2014 [1]
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Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening
期刊论文
Bioorganic chemistry, 2019, 卷号: 86, 页码: 494-500
作者:
Zhang Dan[1]
;
Han Jie[2]
;
Lu Wenchao[3]
;
Lian Fulin[4]
;
Wang Jun[5]
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/04/22
BPTF inhibitor
Bromodomain
Lysine acetylation
Virtual screening
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 页码: 4917-4924
作者:
Tao, Hongru[1]
;
Wang, Jun[2]
;
Lu, Wenchao[3]
;
Zhang, Rukang[4]
;
Xie, Yiqian[5]
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/04/22
Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies
期刊论文
MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 页码: 914-950
作者:
Zheng, Mingyue[1]
;
Zhao, Jihui[2]
;
Cui, Chen[3]
;
Fu, Zunyun[4]
;
Li, Xutong[5]
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/04/22
ADMET
chemical biology
drug design
in silico
lead optimization
molecular dynamics
polypharmacology
virtual screening
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors
期刊论文
Bioorganic & medicinal chemistry, 2018, 卷号: 26, 页码: 5397-5407
作者:
Lu Wenchao[1]
;
Xiong Huan[2]
;
Chen Yu[3]
;
Wang Chen[4]
;
Zhang Hao[5]
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/04/22
Drug discovery
Epigenetics
Histone acetyltransferase
P300/CBP
Predicting Hepatotoxicity of Drug Metabolites Via an Ensemble Approach Based on Support Vector Machine
期刊论文
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2017, 卷号: 20, 页码: 839-849
作者:
Lu, Yin[1]
;
Liu, Lili[2]
;
Lu, Dong[3]
;
Cai, Yudong[4]
;
Zheng, Mingyue[5]
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/04/26
DILI
hepatotoxicity
QSAR
drug metabolites
mRMR
SVM
Nine sesquiterpenes from Solanum torvum
期刊论文
Natural product research, 2016, 卷号: 30, 页码: 1682-9
作者:
Yuan Pulong[1]
;
Guo Fujiang[2]
;
Zheng Kaikai[3]
;
Chen Kaixian[4]
;
Jia Qi[5]
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/04/26
13C NMR
Solanum torvum
epimers
sesquiterpenes
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
期刊论文
Diabetologia, 2016, 卷号: 59, 页码: 1276-86
作者:
Feng Li[1]
;
Luo Huan[2]
;
Xu Zhijian[3]
;
Yang Zhuo[4]
;
Du Guoxin[5]
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/04/26
Alternative binding site
Bavachinin
Canonical ligand-binding pocket
Carbohydrate metabolism
Lipid metabolism
Pan-PPAR agonist
Synergistic effects
Rapid identification of α-glucosidase inhibitors from Phlomis tuberosa by Sepbox chromatography and thin-layer chromatography bioautography
期刊论文
PloS one, 2015, 卷号: 10, 页码: e0116922
作者:
Yang Yingbo[1]
;
Gu Lihua[2]
;
Xiao Ying[3]
;
Liu Qing[4]
;
Hu Haijun[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/30
Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress
期刊论文
PloS one, 2015, 卷号: 10, 页码: e0132411
作者:
Zhou Yuren[1]
;
Sun Peng[2]
;
Wang Ting[3]
;
Chen Kaixian[4]
;
Zhu Weiliang[5]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/04/30
Metabolism of diosbulbin B in vitro and in vivo in rats: formation of reactive metabolites and human enzymes involved
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2014, 卷号: 42, 页码: 1737-50
作者:
Yang Baohua[1]
;
Liu Wei[2]
;
Chen Kaixian[3]
;
Wang Zhengtao[4]
;
Wang Changhong[5]
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/04/30
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