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科研机构
上海药物研究所 [4]
复旦大学上海医学院 [2]
上海有机化学研究所 [1]
内容类型
期刊论文 [4]
图书章节 [2]
会议论文 [1]
发表日期
2018 [2]
2017 [2]
2016 [1]
2013 [1]
2008 [1]
学科主题
生命有机化学 [1]
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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 15, 页码: 6685-6704
作者:
Qin, Chong
;
Hu, Yang
;
Zhou, Bing
;
Fernandez-Salas, Ester
;
Yang, Chao-Yie
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 14, 页码: 6110-6120
作者:
Zhao, Yujun
;
Zhou, Bing
;
Bai, Longchuan
;
Liu, Liu
;
Yang, Chao-Yie
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 9, 页码: 3887-3901
作者:
Zhao, Yujun
;
Bai, Longchuan
;
Liu, Liu
;
McEachern, Donna
;
Stuckey, Jeanne A.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Discovery of a new class of highly potent small-molecule degraders of BET bromodomain proteins
会议论文
作者:
Xu, Fuming
;
Hu, Jiantao
;
Zhou, Bing
;
Chen, Zhuo
;
Lin, Mei
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Pain
图书章节
2016
作者:
Chen, Jun/55949816100[0]
;
Han, Ji Sheng/7406440802[1]
;
Zhao, Zhiqi/57194153054[2]
;
Wei, Feng/8837475400[3]
;
Hsieh, Jenchuen/7401435679[4]
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/05
Acupuncture modulation
Acupuncture modulation of pain
Amygdala
Axonal reflex
Behavioral pain hypersensitivity
Bell-magendie law
Biochemical neuroimaging
Brain matrix
Brain mechanisms
Cerebellum
Cortical and subcortical processing
Disinhibition
Drug modulation
Functional neuroimaging
Gabapentin
Gatecontrol theory of pain
Gene therapy and stem cell treatment
Glial cells
Hyperalgesia
Hypothalamus
Insula
K2P
Nerve injury-induced neural plasticity
Neurochemical markers
Neurogenic inflammation
Neuromodulation
Neuromodulation
Neuropathic
Nociception
Nociceptive flexion reflex (NFR)
Nociceptive specific (NS) neurons
Nonsteroidal anti-inflammatory drugs (NSAIDs)
P2X3 receptor
P2Y receptors
Pain
Pain
Pain
Pain
Pain
Pain
Pain matrix
Peptidergic population of c nociceptors
Periaqueductal gray (PAG)
Peripheral mechanisms
Peripheral nociceptors
Placebo modulation
Placebo modulation
Primary afferent depolarization (PAD)
Pro-inflammatory cytokines
Psychological modulation
Rostral ventromedial medulla (RVM)
Specificity theory
Spinal cord dorsal horn
Spinal pain sensory neurons
Structural neuroimaging
Tanezumab
Thalamic pain syndrome
Transient receptor potential vanilloid receptor 1 (TRPV1)
Tripartite synaptic model
Vanilloid receptor-like protein 1 (VRL1)
Ventrolateral orbital cortex (VLO)
Voltage-gated potassium channels (VGPCs)
Voxel-based morphometry
Windup phenomenon
Pain
图书章节
2013
作者:
Chen, Jun/55949816100[0]
;
Han, Ji Sheng/7406440802[1]
;
Zhao, Zhiqi/7404148138[2]
;
Wei, Feng/8837475400[3]
;
Hsieh, Jenchuen/7401435679[4]
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/19
Design, Synthesis and Evaluation of Tricyclic, Conformationally Constrained Smac Mimetics As Antagonists of IAP Proteins
期刊论文
J. Med. Chem., 2008, 卷号: 51, 期号: 23, 页码: 7352-7355
ZHANG BIN
;
ZANETA NIKOLOVSKA-COLESKA
;
ZHANG YAN
;
BAI LONGCHUAN
;
QIU SU
;
YANG CHAOYIE
;
SUN HAIYING
;
王少萌
;
伍贻康
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2013/02/25
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