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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 15, 页码: 6685-6704
作者:  Qin, Chong;  Hu, Yang;  Zhou, Bing;  Fernandez-Salas, Ester;  Yang, Chao-Yie
收藏  |  浏览/下载:45/0  |  提交时间:2019/01/08
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 14, 页码: 6110-6120
作者:  Zhao, Yujun;  Zhou, Bing;  Bai, Longchuan;  Liu, Liu;  Yang, Chao-Yie
收藏  |  浏览/下载:49/0  |  提交时间:2019/01/08
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 9, 页码: 3887-3901
作者:  Zhao, Yujun;  Bai, Longchuan;  Liu, Liu;  McEachern, Donna;  Stuckey, Jeanne A.
收藏  |  浏览/下载:27/0  |  提交时间:2019/01/08
Discovery of a new class of highly potent small-molecule degraders of BET bromodomain proteins 会议论文
作者:  Xu, Fuming;  Hu, Jiantao;  Zhou, Bing;  Chen, Zhuo;  Lin, Mei
收藏  |  浏览/下载:27/0  |  提交时间:2019/01/08
Pain 图书章节
2016
作者:  Chen, Jun/55949816100[0];  Han, Ji Sheng/7406440802[1];  Zhao, Zhiqi/57194153054[2];  Wei, Feng/8837475400[3];  Hsieh, Jenchuen/7401435679[4]
收藏  |  浏览/下载:37/0  |  提交时间:2019/12/05
Acupuncture modulation  Acupuncture modulation of pain  Amygdala  Axonal reflex  Behavioral pain hypersensitivity  Bell-magendie law  Biochemical neuroimaging  Brain matrix  Brain mechanisms  Cerebellum  Cortical and subcortical processing  Disinhibition  Drug modulation  Functional neuroimaging  Gabapentin  Gatecontrol theory of pain  Gene therapy and stem cell treatment  Glial cells  Hyperalgesia  Hypothalamus  Insula  K2P  Nerve injury-induced neural plasticity  Neurochemical markers  Neurogenic inflammation  Neuromodulation  Neuromodulation  Neuropathic  Nociception  Nociceptive flexion reflex (NFR)  Nociceptive specific (NS) neurons  Nonsteroidal anti-inflammatory drugs (NSAIDs)  P2X3 receptor  P2Y receptors  Pain  Pain  Pain  Pain  Pain  Pain  Pain matrix  Peptidergic population of c nociceptors  Periaqueductal gray (PAG)  Peripheral mechanisms  Peripheral nociceptors  Placebo modulation  Placebo modulation  Primary afferent depolarization (PAD)  Pro-inflammatory cytokines  Psychological modulation  Rostral ventromedial medulla (RVM)  Specificity theory  Spinal cord dorsal horn  Spinal pain sensory neurons  Structural neuroimaging  Tanezumab  Thalamic pain syndrome  Transient receptor potential vanilloid receptor 1 (TRPV1)  Tripartite synaptic model  Vanilloid receptor-like protein 1 (VRL1)  Ventrolateral orbital cortex (VLO)  Voltage-gated potassium channels (VGPCs)  Voxel-based morphometry  Windup phenomenon  
Pain 图书章节
2013
作者:  Chen, Jun/55949816100[0];  Han, Ji Sheng/7406440802[1];  Zhao, Zhiqi/7404148138[2];  Wei, Feng/8837475400[3];  Hsieh, Jenchuen/7401435679[4]
收藏  |  浏览/下载:19/0  |  提交时间:2019/12/19
Design, Synthesis and Evaluation of Tricyclic, Conformationally Constrained Smac Mimetics As Antagonists of IAP Proteins 期刊论文
J. Med. Chem., 2008, 卷号: 51, 期号: 23, 页码: 7352-7355
ZHANG BIN; ZANETA NIKOLOVSKA-COLESKA; ZHANG YAN; BAI LONGCHUAN; QIU SU; YANG CHAOYIE; SUN HAIYING; 王少萌; 伍贻康
收藏  |  浏览/下载:12/0  |  提交时间:2013/02/25


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