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Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 4, 页码: 1844-1855
作者:  Zhou, Yu;  Fu, Yan;  Yin, Wanchao;  Li, Jian;  Wang, Wei
收藏  |  浏览/下载:21/0  |  提交时间:2021/05/24
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
收藏  |  浏览/下载:137/0  |  提交时间:2019/06/28
Synthesis of beta-Keto Sulfones via Coupling of Aryl/Alkyl Halides, Sulfur Dioxide and Silyl Enolates through Metal-Free Photoinduced C-X Bond Dissociation 期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2017, 卷号: 359, 期号: 17
作者:  Gong, Xinxing;  Ding, Yechun;  Fan, Xiaona;  Wu, Jie
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/05
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:  Gong, Xudong;  Wang, Guan;  Ren, Jing;  Liu, Zheng;  Wang, Zhen
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen
收藏  |  浏览/下载:36/0  |  提交时间:2013/11/07
Molecular cloning and heterologous expression of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus x media 期刊论文
MOLECULAR BIOLOGY REPORTS, 2007, 卷号: 34, 期号: 2
作者:  Guo, Binhui;  Kai, Guoyin;  Gong, Yifu;  Jin, Hongbin;  Wang, Yechun
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/27
小儿智能发育的诊断 期刊论文
优生与遗传, 1988, 期号: 0, 页码: 56-60
作者:  龚业纯
收藏  |  浏览/下载:0/0  |  提交时间:2016/09/09
兰州小儿伤寒、副伤寒300例临床分析 期刊论文
兰州医学院学报, 1960, 期号: 3, 页码: 75-84
作者:  张克信;  龚业纯;  章世桢;  黄宝润
收藏  |  浏览/下载:11/0  |  提交时间:2016/09/12


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