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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:  Zheng, Yuan-dong;  Zhang, Hua;  Zhan, Yan;  Bian, Yi-cong;  Ma, Sheng
收藏  |  浏览/下载:43/0  |  提交时间:2021/05/24
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:  Li, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载:102/0  |  提交时间:2019/01/08
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127
作者:  Liu, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载:26/0  |  提交时间:2019/12/05
Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:  Li, Xiaojiao;  Liu, Ca;  Zhu, Xiaoxue;  Wei, Haijing;  Zhang, Hong
收藏  |  浏览/下载:57/0  |  提交时间:2019/01/08
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 149, 页码: 394-402
作者:  Liu, Cai;  Lu, Youming;  Sun, Hongbin;  Yang, Jin;  Liu, Yongqiang
收藏  |  浏览/下载:32/0  |  提交时间:2019/01/08
Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:  Li, Xiaojiao;  Liu, Ca;  Zhu, Xiaoxue;  Wei, Haijing;  Zhang, Hong
收藏  |  浏览/下载:15/0  |  提交时间:2019/12/05
Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans 期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:  Jiang, Jinfang;  Chen, Xiaoyan;  Zhong, Dafang
收藏  |  浏览/下载:32/0  |  提交时间:2019/01/08
METABOLISM AND PHARMACOKINETICS OF VICAGREL, A NOVEL THIENOPYRIDINE P2Y12 INHIBITOR, COMPARED WITH CLOPIDOGREL IN HEALTHY CHINESE SUBJECTS 会议论文
作者:  Liu, Cai;  Chen, Xiaoyan;  Zhong, Dafang
收藏  |  浏览/下载:26/0  |  提交时间:2019/01/08
Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration 期刊论文
MOLECULES, 2016, 卷号: 21, 期号: 6
作者:  Xu, Xueyu;  Zhao, Xue;  Yang, Zhichao;  Wang, Hao;  Meng, Xiangjun
收藏  |  浏览/下载:15/0  |  提交时间:2019/12/05
Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel 期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 10, 页码: 1632-1641
作者:  Liu, Cai;  Chen, Zhaoqiang;  Zhong, Kan;  Li, Liang;  Zhu, Weiliang
收藏  |  浏览/下载:27/0  |  提交时间:2019/01/08


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