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科研机构
山东大学 [11]
上海药物研究所 [1]
四川大学 [1]
中国医学科学院 北京... [1]
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期刊论文 [14]
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2019 [1]
2018 [3]
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Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 卷号: 13, 页码: 3217-3228
作者:
Wang, Yanjun
;
Pang, Bo
;
Zhang, Rui
;
Fu, Yibing
;
Pang, Qi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
pituitary
ubenimex
autophagy
apoptosis
ROS
Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells
期刊论文
ONCOTARGETS AND THERAPY, 2018, 卷号: 11, 页码: 943-953
作者:
Wang, Xiaoqing
;
Liu, Yang
;
Wu, Rongde
;
Guo, Feng
;
Zhang, Lijuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
melanoma
ubenimex
jnk
Akt
mixed cell death
metastasis
Synthesis and biological characterization of ubenimex-fluorouracil conjugates for anti-cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 334-347
作者:
Jiang, Yuqi
;
Li, Xiaoyang
;
Hou, Jinning
;
Huang, Yongxue
;
Wang, Xuejian
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
CD13 inhibitor
Conjugate
Liver cancer
Anticancer
Pharmacokinetic
Ubenimex, an APN inhibitor, could serve as an anti-tumor drug in RT112 and 5637 cells by operating in an Akt-associated manner
期刊论文
MOLECULAR MEDICINE REPORTS, 2018, 卷号: 17, 期号: 3, 页码: 4531-4539
作者:
Wang, Xiaoqing
;
Liu, Yang
;
Liu, Wei
;
Zhang, Yongfei
;
Guo, Feng
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/11
ubenimex
autophagic cell death
aminopeptidase N
apoptosis
Akt
signaling pathway
Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107730-107743
作者:
Han, Liping
;
Zhang, Yongfei
;
Liu, Shuai
;
Zhao, Qingwei
;
Liang, Xianhong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/12
glioma
ubenimex
G2/M phase arrest
autophagic flux
apoptosis
Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells
期刊论文
ONCOLOGY REPORTS, 2016, 卷号: 35, 期号: 4, 页码: 2121-2130
作者:
Wang, Xiaoqing
;
Niu, Zhihong
;
Jia, Yang
;
Cui, Meng
;
Han, Liping
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/16
ubenimex
APN
prostate cancer
autophagic cell death
Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death
期刊论文
ONCOLOGY LETTERS, 2016, 卷号: 12, 期号: 5, 页码: 3403-3410
作者:
Liu, Shuai
;
Wang, Xiaoqing
;
Lu, Jiaju
;
Han, Liping
;
Zhang, Yongfei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
ubenimex
radiosensitivity
RCC
autophagic cell death
Akt
Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 48, 页码: 79127-79139
作者:
Liu, Shuai
;
Gao, Mingwei
;
Wang, Xiaoqing
;
Ding, Sentai
;
Lv, Jiaju
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/16
renal cell carcinoma
sorafenib resistance
lipophagy
Akt pathway
ubenimex
Discovery of BC-01, a novel mutual prodrug (hybrid drug) of ubenimex and fluorouracil as anticancer agent
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 121, 页码: 649-657
作者:
Jiang, Yuqi
;
Li, Xiaoyang
;
Hou, Jinning
;
Huang, Yongxue
;
Jia, Yuping
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/16
CD13
Ubenimex
Mutual prodrug
Antitumor
Anti-metastasis
Liver cancer
Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 22, 页码: 5787-5795
作者:
Jiang, Yuqi
;
Hou, Jinning
;
Li, Xiaoyang
;
Huang, Yongxue
;
Wang, Xuejian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/16
CD13 inhibitor
Ubenimex
Gemcitabine (GEM)
Anti-angiogenesis
Anticancer
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