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科研机构
复旦大学上海医学院 [2]
化学研究所 [1]
上海药物研究所 [1]
华中师范大学 [1]
内容类型
期刊论文 [5]
发表日期
2017 [1]
2015 [1]
2013 [1]
2009 [1]
2002 [1]
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Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112
作者:
Ji, Yue-Yang
;
Lin, Sen-Dong
;
Wang, Yu-Jie
;
Su, Ming-Bo
;
Zhang, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Tranylcypromine
LSD1
Stereoselective cyclopropanation
Chiral synthesis
MAO-A
MAO-B
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:
Liu, Ke
;
Liu, Yanli
;
Lau, Johnathan L
;
Min, Jinrong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Histone demethylation
DNA methylation
Inhibitor
Chemical probe
Drug discovery
LSD
lysine-specific histone demethylase
HDAC
histone deacetylase
REST
REST corepressor
DNMT
DNA methyltransferase
MAO
monoamine oxidase
AML
acute myeloid leukemia
KDM
lysine-specific demethylase
MLL
mixed lineage leukemia
FAD
flavin adenine dinucleotide
PCPA
trans-2-phenylcyclopropylamine
2,4-PDCA
2, 4-pyridinedicarboxylic acid
PHD
plant homeobox domain
SCLC
small cell lung cancer
JHDMs
JmjC-domain-containing histone demethylases
NOG
N-oxalylglycine
IOX1
5-carboxy-8-hydroxyquinoline
MDS
myelodysplastic syndrome
2-OG, 2-oxoglutarate or
α-ketoglutarate
G9a
euchromatic histone-lysine N-methyltransferase 2
CoREST complex
restin corepressor complex
SAH
S-adenosyl-l-homocysteine
l
SWI complex
ATP dependent chromatin remodeling complexes
Pan-Histone Demethylase Inhibitor
the inhibitor can simultaneously inhibit both LSDs and JHDMs
LSC colony
leukemic stem cell colony
Pan JmjC domain-containing demethylase inhibitor
the inhibitor can simultaneously inhibit all the members of JHDMs
E2F1
E2F transcription factor 1
E2F2
E2F transcription factor 2
RCC
renal cell carcinoma
Trans-2-phenylcyclopropylamine regulates zebrafish lateral line neuromast development mediated by depression of LSD1 activity
期刊论文
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2013, 卷号: 57, 期号: 5
作者:
He, Yingzi
;
Yu, Huiqian
;
Sun, Shan
;
Wang, Yunfeng
;
Liu, Liman
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
hair cell
LSD1
neuromast
trans-2-phenylcydopropylamine
zebrafish
Trans-2-phenylcyclopropylamine induces nerve cells apoptosis in zebrafish mediated by depression of LSD1 activity
期刊论文
BRAIN RESEARCH BULLETIN, 2009, 卷号: 80, 期号: 1-2
作者:
Zhang Jie
;
Tan Li
;
Hou Jia-Yun
;
Jiang Qiu
;
Zen Ping-Yao
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/19
Trans-2-phenylcyclopropylamine
Zebrafish
Apoptosis
LSD1
Nerve cell
p53
A novel approach to enantiopure cyclopropane compounds from biotransformation of nitriles
期刊论文
NEW JOURNAL OF CHEMISTRY, 2002, 卷号: 26, 期号: 11, 页码: 1575-1583
作者:
Wang, MX
;
Feng, GQ
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  |  
浏览/下载:15/0
  |  
提交时间:2019/04/09
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