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上海药物研究所 [3]
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期刊论文 [12]
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Enhanced 2-O-alpha-D-Glucopyranosyl-L-ascorbic Acid Synthesis through Iterative Saturation Mutagenesis of Acceptor Subsite Residues in Bacillus stearothermophilus NO2 Cyclodextrin Glycosyltransferase
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 卷号: Vol.66 No.34, 页码: 9052-9060
作者:
Tao, Xiumei
;
Wang, Tian
;
Su, Lingqia
;
Wu, Jing
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/26
2-O-alpha-D-glucopyranosyl-L-ascorbic
acid
cyclodextrin
glycosyltransferase
L-ascorbic
acid
specificity
acceptor
subsite
iterative
saturation
mutagenesis
Structures of PspAG97A α-Glucoside Hydrolase Reveal a Novel Mechanism for Chloride Induced Activation.
期刊论文
Journal of Structural Biology, 2016, 卷号: Vol.196 No.3, 页码: 426-436
作者:
Yi Xue
;
Wei Li
;
Chao He
;
Yazhong Xiao
;
Zeming Fang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/04/22
Crystal
structure
Enzyme
Halophilic
Subsite
Substrate
specificity
Enhancement of alpha-cyclodextrin product specificity by enriching histidines of alpha-cyclodextrin glucanotransferase at remote subsite-6
期刊论文
PROCESS BIOCHEMISTRY, 2014, 卷号: 49, 期号: 2, 页码: 230-236
作者:
Yue, Yang
;
Song, Binghong
;
Xie, Ting
;
Sun, Yan
;
Chao, Yapeng
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2016/06/23
alpha-Cyclodextrin glucanotransferases
alpha-Cyclodextrin Product specificity
Site-directed mutagenesis
Enzymatic properties
Mutation of Tyrosine167Histidine at Remote Substrate Binding Subsite-6 in alpha-Cyclodextrin Glycosyltransferase Enhancing alpha-Cyclodextrin Specificity by Directed Evolution
期刊论文
MOLECULAR BIOTECHNOLOGY, 2014, 卷号: 56, 页码: 232-239
作者:
Song, Binghong
;
Yue, Yang
;
Xie, Ting
;
Qian, Shijun
;
Chao, Yapeng
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/01/06
alpha-Cyclodextrin glycosyltransferase
Directed evolution
Reverse mutation
Saturated mutagenesis
Enhancement of alpha-cyclodextrin product specificity by enriching histidines of alpha-cyclodextrin glucanotransferase at remote subsite-6
期刊论文
PROCESS BIOCHEMISTRY, 2014, 卷号: 49, 页码: 230-236
作者:
Yue, Yang
;
Song, Binghong
;
Xie, Ting
;
Sun, Yan
;
Chao, Yapeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/06
alpha-Cyclodextrin glucanotransferases
alpha-Cyclodextrin Product specificity
Site-directed mutagenesis
Enzymatic properties
Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 卷号: 45, 期号: 8, 页码: 613-621
作者:
Li Xiaoman
;
Hong Lin
;
Coughlan Kathleen
;
Wang Liang
;
Cao Liu
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2021/02/02
AMYLOID PRECURSOR PROTEIN
BETA-SECRETASE BACE1
GATED SODIUM-CHANNELS
CLEAVING ENZYME
GGA PROTEINS
ASPARTYL PROTEASE
NEURONAL-ACTIVITY
GENETIC DELETION
CYTOSOLIC DOMAIN
ALPHA-SECRETASE
memapsin 2
BACE1
beta-amyloid
subsite specificity
activity prediction
Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 卷号: 45, 期号: 8, 页码: 613-621
作者:
Li Xiaoman
;
Hong Lin
;
Coughlan Kathleen
;
Wang Liang
;
Cao Liu
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2021/02/02
AMYLOID PRECURSOR PROTEIN
BETA-SECRETASE BACE1
GATED SODIUM-CHANNELS
CLEAVING ENZYME
GGA PROTEINS
ASPARTYL PROTEASE
NEURONAL-ACTIVITY
GENETIC DELETION
CYTOSOLIC DOMAIN
ALPHA-SECRETASE
memapsin 2
BACE1
beta-amyloid
subsite specificity
activity prediction
Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design
期刊论文
JOURNAL OF VIROLOGY, 2011, 卷号: 85, 期号: 19, 页码: 10319-10331
作者:
Lu, Guangwen
;
Qi, Jianxun
;
Chen, Zhujun
;
Xu, Xiang
;
Gao, Feng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Predicting memapsin 2 (beta-secretase) hydrolytic activity
期刊论文
PROTEIN SCIENCE, 2010, 卷号: 19, 期号: 11, 页码: 2175-2185
Li, Xiaoman
;
Bo, Huang
;
Zhang, Xuejun C
;
Hartsuck, Jean A
;
Tang, Jordan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2013/12/24
memapsin 2
BACE1
beta-secretase
subsite specificity
activity prediction
beta-amyloid
Alzheimer's disease
Molecular basis of the recognition process: Hydrogen-bonding patterns in the guanine primary recognition site of ribonuclease T1
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 卷号: 110, 期号: 27, 页码: 13590-13596
作者:
Gu, Jiande
;
Wang, Jing
;
Leszczynski, Jerzy
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
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