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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Discovery of betulinaldehyde as a natural ROR gamma t agonist
期刊论文
FITOTERAPIA, 2019, 卷号: 137, 页码: 8
作者:
Yang, Feng
;
Zhang, Ruihan
;
Ni, Dongxuan
;
Luo, Xiaomin
;
Chen, Shijie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
ROR gamma t
Receptor agonist
Triterpenoids
Alpha screen
Molecular docking
Type 3 innate lymphoid cells are altered in colons of C57BL/6 mice with dioxin exposure
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 662, 页码: 639-645
作者:
Li, Yunping
;
Xie, Heidi Qunhui
;
Zhang, Wanglong
;
Wei, Yunbo
;
Sha, Rui
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/10/21
TCDD
ILC3
ROR gamma t
IL-17a
IFN-gamma
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer
期刊论文
CANCER RESEARCH, 2019, 卷号: 79, 期号: 10
作者:
Zhu, Yao
;
Cao, Dalong
;
Qi, Zihao
;
Pang, Yangyang
;
Li, Haoran
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  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
Retinoic acid receptor-related orphan receptor gamma-t (ROR gamma t) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 9
作者:
Sun, Nannan
;
Wang, Yonghui
;
Guo, Huimin
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  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
ROR gamma t
Th17
IL-17
inhibitors
autoimmune diseases
Retinoic acid-related orphan receptor C regulates proliferation, glycolysis, and chemoresistance via the PD-L1/ITGB6/STAT3 signaling axis in bladder cancer
期刊论文
Cancer research, 2019
作者:
Cao Dalong[1]
;
Qi Zihao[2]
;
Pang Yangyang[3]
;
Li Haoran[4]
;
Xie Huyang[5]
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/04/22
Retinoic acid-related orphan receptor C regulates proliferation, glycolysis, and chemoresistance via the PD-L1/ITGB6/STAT3 signaling axis in bladder cancer.
期刊论文
Cancer research, 2019
作者:
Ziliang Wang
;
Dalong Cao
;
Zihao Qi
;
Yangyang Pang
;
Haoran Li
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/17
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer
期刊论文
CANCER RESEARCH, 2019, 卷号: 79, 期号: 10
作者:
Cao, Dalong
;
Qi, Zihao
;
Pang, Yangyang
;
Li, Haoran
;
Xie, Huyang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/06
A Drug with Lipophilicity-Dependent Potency Can Be Metabolically Stable: Discovery of a Potent and Selective Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist as an Orally Bioavailable Anti-Inflammatory Agent
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 23, 页码: 10412-10414
作者:
Wang, Yibing
;
Liu, Hong
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/01/08
Retinoic Acid Receptor-Related Orphan Receptor gamma t (ROR gamma t) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 14
作者:
Qiu, Ruomeng
;
Wang, Yonghui
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  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
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