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Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 4435-4442
作者:
Meng, Fan-Jie
;
Shi, Lei
;
Feng, Guang-Shou
;
Sun, Lei
;
Zhou, Yong-Gui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/02
Enantioselectivity
Selective catalytic reduction, Chemoselective
Enantioselective synthesis
Hantzsch
Hydrogen sources
Organocatalytic
Stereogenic centers
Transfer hydrogenations, Hydrogenation, 3,4 dihydropyrimidin 2(1h)one
pyrimidine derivative
unclassified drug, Article
asymmetric synthesis
biomimetics
chirality
enantioselectivity
hydrogenation
7-H-Pyrrolo[2,3-d]pyrimidine derivative acts as promising agent for gastric cancer treatment by inducing cell death
期刊论文
3 Biotech, 2019, 卷号: 9, 期号: 11
作者:
Zhang X.
;
Zhang J.
;
Liu F.
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Autophagy
Caspase
Chromatin condensation
Necroptosis
Oral administration of indole substituted dipyrido[2,3-d]pyrimidine derivative exhibits anti-tumor activity via inhibiting AKT and ERK1/2 on hepatocellular carcinoma.
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018
作者:
Yao, Hong
;
Yan, Hongru
;
Gao, Xiaoge
;
Zhu, Songlei
;
Cen, Lanqi
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/31
Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452
期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 4, 页码: -136
作者:
Zhong, WM
;
Wang, JF
;
Shi, XF
;
Wei, XY
;
Chen, YC
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2018/08/24
Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors
期刊论文
FRONTIERS IN CHEMISTRY, 2017, 卷号: 5
作者:
Hu, Xiuqin
;
Wang, Disha
;
Tong, Yi
;
Tong, Linjiang
;
Wang, Xia
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/01/08
EGFR
tyrosine kinase inhibitors
anilinopyrtmidine
glycosides
carbohydrate-based drugs
Synthesis, Crystal Structure and Biological Evaluation of 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl)thioacetyl] Mutilin
期刊论文
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2017, 卷号: 36, 页码: 1327-1333
作者:
Zhou Xiang
;
Li Xue-Hu
;
Yi Yun-Peng
;
Lu Xi-Hong
;
Wang Liang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2018/05/31
pleuromutilin derivative
single-crystal structure
antibacterial activities
Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
期刊论文
CANCER SCIENCE, 2016, 卷号: 107, 期号: 6, 页码: 782-790
作者:
Wang, Wenqian
;
Liu, Yang
;
Zhao, Zhixin
;
Xie, Chengying
;
Xu, Yongping
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Hop
Hsp90
imatinib resistance
thiol oxidation
Y-632
An improved synthesis approach of the HIV-1 inhibitor RDEA427, a pyrrolo[2,3-d]pyrimidine derivative
期刊论文
ARKIVOC, 2016, 页码: 45-51
作者:
Huang, Boshi
;
Liu, Xinhao
;
Li, Wanzhuo
;
Chen, Zihui
;
Kang, Dongwei
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/17
HIV-1 inhibitor
RDEA427
diarylpyrimidine-like derivative
increased
overall yield
environment-friendly
Structural insight into substrate preference for TET- mediated oxidation
期刊论文
NATURE, 2015, 卷号: 527, 期号: 7576, 页码: 118-122
作者:
Hu, Lulu
;
Lu, Junyan
;
Cheng, Jingdong
;
Rao, Qinhui
;
Li, Ze
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
A New Pleuromutilin Derivative: Synthesis, Crystal Structure and Antibacterial Evaluation
期刊论文
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2015, 卷号: 34, 期号: 9, 页码: 1434-1439
作者:
Yi, YP
;
Yang, GZ
;
Guo, ZT
;
Ai, X
;
Shang, RF
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/01/11
pleuromutilin
single-crystal structure
antibacterial activities
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