×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
昆明植物研究所 [1]
内容类型
期刊论文 [1]
发表日期
2013 [1]
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共1条,第1-1条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
©版权所有 ©2017 CSpace - Powered by
CSpace