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Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors
期刊论文
BMC Medicine, 2022, 卷号: 20, 期号: 1
作者:
Zhang,Pei
;
Du,Yang
;
Bai,Hua
;
Wang,Zhijie
;
Duan,Jianchun
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2022/11/21
Tucidinostat
Tumor microenvironment
PD-L1
CCL5
Solid tumor
Effects of the non-chlorine oxidizer potassium monopersulfate on the water quality, growth performance and microbial community of Pacific white shrimp (Penaeus vannamei) culture systems with limited water exchange
期刊论文
AQUACULTURE RESEARCH, 2022, 页码: 13
作者:
Zhao, Zhen
;
Wang, Baojie
;
Liu, Mei
;
Jiang, Keyong
;
Wang, Lei
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  |  
浏览/下载:16/0
  |  
提交时间:2022/07/18
growth performance
microbial community
Penaeus vannamei
potassium peroxomonosulfate compound (KMPC)
water quality
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
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  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
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  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2021, 卷号: 34
作者:
Hu, Kunyu
;
Xu, Yun
;
Xu, Shengmin
;
Cheng, Lei
;
Zhou, Tong
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  |  
浏览/下载:27/0
  |  
提交时间:2021/06/15
Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Henagliflozin, a Novel Selective Inhibitor of Sodium-Glucose Cotransporter 2, in Healthy Subjects Following Single- and Multiple-dose Administration
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 2, 页码: 396-409
作者:
Zhang, Yi-fan
;
Liu, Yan-mei
;
Yu, Chen
;
Wang, Ya-ting
;
Zhan, Yan
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  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
diabetes
henagliflozin
pharmacodynamics
pharmacokinetics
SGLT-2 inhibitors
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
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  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Comparison of Equivalent Doses Obtained with Various post-IR IRSL Dating Protocols of K-Feldspar
期刊论文
GEOCHRONOMETRIA, 2021, 卷号: 48, 期号: 1, 页码: 129-137
作者:
Zhang, Junjie
;
Li, Sheng-Hua
;
Wang, Xulong
;
Hao, Qingzhen
;
Hu, Guiming
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  |  
浏览/下载:10/0
  |  
提交时间:2022/08/19
Chinese loess
Potassium feldspar
pIRIR protocols
age underestimations
Allelopathic effects of mixotrophic dinoflagellate Akashiwo sanguinea on co-occurring phytoplankton: the significance of nutritional ecology
期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2020, 页码: 15
作者:
Yang Yeyin
;
Huang Bozhu
;
Tang Yingzhong
;
Xu Ning
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/04/12
Akashiwo sanguinea
harmful algal blooms
mixotrophy
allelopathy
nutrients
Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2020, 卷号: 19, 期号: 11, 页码: 2340-2352
作者:
Jin, Rui
;
Liu, Liang
;
Xing, Yun
;
Meng, Tao
;
Ma, Lanping
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  |  
浏览/下载:49/0
  |  
提交时间:2020/12/24
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