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浏览/检索结果: 共1条，第1-1条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Profile of minocycline and its potential in the treatment of schizophrenia 期刊论文 Neuropsychiatric Disease and Treatment, 2014, 卷号: 10, 页码: 1103-1111 作者:  Zhang, Lulu;  Zhao, Jingping* 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia  and appropriate control of microglial activation may be a promising therapeutic strategy for schizophrenia. Minocycline  a second-generation tetracycline that inhibits microglial activation  has been shown to have a neuroprotective effect in various models of neurodegenerative disease  including anti-inflammatory  antioxidant  and antiapoptotic properties  and an ability to modulate glutamate-induced excitotoxicity. Given that these mechanisms overlap with neuropathologic pathways  minocycline may have a potential role in the adjuvant treatment of schizophrenia  and improve its negative symptoms. Here  we review the relevant studies of minocycline  ranging from preclinical research to human clinical trials.