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科研机构
大连化学物理研究所 [6]
清华大学 [1]
上海药物研究所 [1]
湖南大学 [1]
内容类型
期刊论文 [8]
会议论文 [1]
发表日期
2019 [3]
2015 [1]
2011 [2]
2010 [1]
2009 [2]
学科主题
分析化学 [1]
物理化学 [1]
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Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
期刊论文
MEDICINE, 2019, 卷号: 98, 期号: 31, 页码: 11
作者:
Ma, Zhenhua
;
Wang, Xiaomei
;
Yin, Peiyuan
;
Wu, Ruihong
;
Zhou, Lina
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/12/02
bile acid
biomarkers
drug induced liver injury
serum metabolic profiling
UHPLC-MS/MS
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior
期刊论文
Frontiers in behavioral neuroscience, 2015, 卷号: 9, 页码: 70
作者:
Huang, Fei
;
Wang, Tingting
;
Lan, Yunyi
;
Yang, Li
;
Pan, Weihong
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer
期刊论文
journal of proteome research, 2011, 卷号: 10, 期号: 5, 页码: 2625-2632
作者:
Chen, Jing
;
Zhang, Xiaoyan
;
Cao, Rui
;
Lu, Xin
;
Zhao, Sumin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2012/07/09
metabolomics
LC-MS
biomarker discovery
epithelium ovarian cancer
27-nor-5 beta-cholestane-3
7
12
24
25 pentol glucuronide
Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
会议论文
37th international symposium on high performance liquid phase separations and related techniques, 大连, 2011-10-8
周丽娜
;
QuancaiWang
;
尹沛源
;
WenbinXing
;
吴泽明
;
陈世礼
;
路鑫
;
YongZhang
;
林晓惠
;
许国旺
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2012/07/09
日本救心丹多维指纹图谱研究
期刊论文
2010, 2010
张敏
;
王义明
;
罗国安
;
ZHANG Min
;
WANG Yi-ming
;
LUO Guo-an
收藏
  |  
浏览/下载:5/0
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?
期刊论文
american journal of physiology-endocrinology and metabolism, 2009, 卷号: 296, 期号: 2, 页码: e384-e393
作者:
Zhao, Xinjie
;
Peter, Andreas
;
Fritsche, Jens
;
Elcnerova, Michaela
;
Fritsche, Andreas
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2010/11/30
metabolomics
metabonomics
oral glucose tolerance test
bile acids
fatty acids
palmitoleate
acylcarnitines
lysophosphatidylcholines
A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry
期刊论文
molecular biosystems, 2009, 卷号: 5, 期号: 8, 页码: 868-876
作者:
Yin, Peiyuan
;
Wan, Dafang
;
Zhao, Chunxia
;
Chen, Jing
;
Zhao, Xinjie
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2010/11/30
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