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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
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  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
Mushroom alcohol controls gray mold caused by Botrytis cinerea in harvested fruit via activating the genes involved in jasmonic acid signaling pathway
期刊论文
POSTHARVEST BIOLOGY AND TECHNOLOGY, 2022, 卷号: 186
作者:
Li, Guangjin
;
Wang, Ying
;
Zhang, Zhanquan
;
Chen, Yong
;
Tian, Shiping
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  |  
浏览/下载:0/0
  |  
提交时间:2024/03/07
1-Octen-3-ol
Botrytis cinerea
Inhibitory effect
Harvested fruit
Resistant
Mechanism
Toxicity and bioavailability of antimony to the earthworm (Eisenia fetida) in different agricultural soils
期刊论文
ENVIRONMENTAL POLLUTION, 2021, 卷号: 291, 页码: 10
作者:
Zhong, Qianyun
;
Li, Lianzhen
;
He, Mengchang
;
Ouyang, Wei
;
Lin, Chunye
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  |  
浏览/下载:19/0
  |  
提交时间:2022/06/16
Sb
Ecotoxicity
Avoidance
Bioaccumulation
Subcellular
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
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  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
期刊论文
GLYCOCONJUGATE JOURNAL, 2021, 页码: 11
作者:
Zeng, Jiaxin
;
Meng, Yuan
;
Chen, Shi-Yi
;
Zhao, Gaofeng
;
Wang, Lianchun
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  |  
浏览/下载:53/0
  |  
提交时间:2021/12/01
Furin
Heparan sulfate
Heparin
Virus infection
Carbohydrate-protein interaction
Mechanisms of bio-additives on boosting enzymatic hydrolysis of lignocellulosic biomass
期刊论文
BIORESOURCE TECHNOLOGY, 2021, 卷号: 337, 页码: 10
作者:
Xu, Chao
;
Alam, Md. Asraful
;
Wang, Zhongming
;
Chen, Huanjun
;
Zhang, Jun
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  |  
浏览/下载:45/0
  |  
提交时间:2021/10/27
Non-enzymatic protein
Biosurfactant
Absorption
Enzymatic hydrolysis
Lignocellulosic biomass
Combining Michaelis-Menten theory and enzyme deactivation reactions for the kinetic study of enzymatic hydrolysis by different pretreated sugarcane bagasse
期刊论文
PROCESS BIOCHEMISTRY, 2021, 卷号: 105, 页码: 72-78
作者:
Zhang, Yu
;
Zhang, Ying
;
Song, Miaojia
;
Topakas, Evangelos
;
Yu, Qiang
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  |  
浏览/下载:52/0
  |  
提交时间:2021/10/27
Enzymatic kinetics
Michaelis-Menten theory
Enzyme deactivation
Cellulase
Xylanase
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
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