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Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
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浏览/下载:74/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
Simultaneous determination of sutetinib and its active metabolite sutetinibN-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 9
作者:
Qiu, Yanan
;
Tang, Chongzhuang
;
Li, Ranran
;
Cao, Sumin
;
Zhang, Yuqiang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
LC-MS
MS
N-oxide
stability
sutetinib
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models
期刊论文
CIRCULATION, 2020, 卷号: 142, 期号: 6, 页码: 556-574
作者:
Yang, Li
;
Han, Bing
;
Zhang, Zhiting
;
Wang, Shuguo
;
Bai, Ying
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
circular RNA
extracellular vesicles
MeCP2 protein
neuronal plasticity
primate
stroke
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
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  |  
浏览/下载:68/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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浏览/下载:45/0
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提交时间:2020/07/01
Bioactivity Prediction Based on Matched Molecular Pair and Matched Molecular Series Methods
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2020, 卷号: 26, 期号: 33, 页码: 4195-4205
作者:
Ding, Xiaoyu
;
Cui, Chen
;
Wang, Dingyan
;
Zhao, Jihui
;
Zheng, Mingyue
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浏览/下载:14/0
  |  
提交时间:2020/12/21
Matched molecular pair
matched molecular series
bioactivity prediction
SAR transfer
application domain
lead optimization
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
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浏览/下载:11/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
Identification of serotonin 2a receptor as a novel hcv entry factor by a chemical biology strategy
期刊论文
Protein & cell, 2019, 卷号: 10, 期号: 3, 页码: 178-195
作者:
Cao, Lin
;
Chen, Jizheng
;
Wang, Yaxin
;
Yang, Yuting
;
Qing, Jie
收藏
  |  
浏览/下载:484/0
  |  
提交时间:2019/05/08
Hcv
Serotonin 2a receptor
Entry
Antiviral drug
Fragment-based drug discovery of triazole inhibitors to block PDE delta-RAS protein-protein interaction
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163, 页码: 597-609
作者:
Chen, Danqi
;
Chen, Yuehong
;
Lian, Fulin
;
Chen, Liu
;
Li, Yanlian
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
PDE delta-RAS
Fragment-based
Inhibitor
Protein-protein interaction
multiplecirculatingsaponinsfromintravenousshenmaiinhibitoatp1bsinvitropotentialjointprecipitantsofdruginteractions
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 6, 页码: 833
作者:
Olaleye Olajide E
;
Niu Wei
;
Du Feifei
;
Wang Fengqing
;
Xu Fang
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/07/01
PANAX-NOTOGINSENG
DOUBLE-BLIND
GINSENG
TRANSPORTERS
INJECTION
IDENTIFICATION
CHROMATOGRAPHY
QUINQUEFOLIUM
CONSTITUENTS
GINSENOSIDES
ShenMai injection
organic anion-transporting polypeptide 1B
drug interactions
ginsenoside
herbal medicine
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