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厦门大学 [3]
北京大学 [1]
上海药物研究所 [1]
大连化学物理研究所 [1]
武汉物理与数学研究所 [1]
中南大学 [1]
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期刊论文 [10]
学位论文 [1]
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2019 [1]
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2012 [3]
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Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism
期刊论文
JOURNAL OF PROTEOME RESEARCH, 2019, 卷号: 18, 期号: 1, 页码: 239-251
作者:
Omiecinski, Curtis J.
;
Patterson, Andrew D.
;
Smith, Philip B.
;
Tian, Yuan
;
Zhang, Limin
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/06/24
NR1I3
constitutive androstane receptor
metabolomics
energy metabolism
Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 卷号: 625, 页码: 657-666
作者:
Gong, Yufeng
;
Zhang, Haijun
;
Geng, Ningbo
;
Xing, Liguo
;
Fan, Jingfeng
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/06/20
Short-chain Chlorinated Paraffins
Thyroid Disruption
Hepatic Metabolism
Thyroid Hormone
Constitutive Androstane Receptor
Prevention of Oxidative Stress by α-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro
期刊论文
Journal of Agricultural and Food Chemistry, 2018, 卷号: 66, 期号: 43, 页码: 11273–11283
作者:
He, Liuqin
;
Wu, Jian
;
Tang, Wenjie
;
Zhou, Xihong*
;
Lin, Qinlu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/28
alpha-ketoglutarate
piglets
constitutive androstane receptor
antioxidant enzymes
oxidative stress
Pregnane X receptor regulates the AhR/Cyp1A1 pathway and protects liver cells from benzo-[α]-pyrene-induced DNA damage
期刊论文
Toxicology Letters, 2017, 卷号: 275, 页码: 67-76
作者:
Cui, Hongmei
;
Gu, Xinsheng
;
Chen, Jingshu
;
Xie, Ying
;
Ke, Sui
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
PXR
pregnane X receptor
AhR
aryl hydrocarbon receptor
DRE
dioxin response element
BaP
benzo[a]pyrene
RIF
rifampicin
H2Ax
histone 2Ax
CAR
constitutive androstane receptor
FXR
farnesoid X receptor
CYP450
cytochrome P450
EROD
7-ethoxyresorufin-O-deethylase
PAH
polycyclic aromatic hydrocarbon
ER
estrogen receptor
PXR
AhR
BaP
cyp1a1
DNA damages
Structure-Dependent Activity of Phthalate Esters and Phthalate Monoesters Binding to Human Constitutive Androstane Receptor
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2015
Zhang, Hong
;
Zhang, Zhaobin
;
Nakanishi, Tsuyoshi
;
Wan, Yi
;
Hiromori, Youhei
;
Nagase, Hisamistu
;
Hu, Jianying
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2017/12/03
NUCLEAR RECEPTOR
LIVER
METABOLITES
ACTIVATION
EXPOSURE
TESTIS
BLOOD
DUST
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2014, 卷号: 87, 期号: 4
作者:
Bing, Yuntao
;
Zhu, Siying
;
Jiang, Kun
;
Dong, Guicheng
;
Li, Jie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Cytochrome P450 2B
Acute stroke
Thyroid hormone
Constitutive androstane receptor
Thyroid hormone receptors
Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2012, 卷号: 40, 期号: 10, 页码: 2031-40
作者:
Sugatani, Junko
;
Uchida, Takahiro
;
Kurosawa, Masatoshi
;
Yamaguchi, Masahiko
;
Yamazaki, Yasuhiro
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism
期刊论文
http://dx.doi.org/10.1016/j.jhep.2011.07.015, 2012
Chen, Tenghui
;
Chen, Qiang
;
Xu, Yixiang
;
Zhou, Qiling
;
Zhu, Jingwei
;
Zhang, Hao
;
Wu, Qiao
;
Xu, Jianming
;
Yu, Chundong
;
俞春东
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2013/12/12
CONSTITUTIVE ANDROSTANE RECEPTOR
NUCLEAR RECEPTOR
IN-VIVO
TRANSCRIPTIONAL COACTIVATOR
LIVER HYPERPLASIA
MITOGEN TCPOBOP
INDUCTION
FAMILY
MICE
HEPATOTOXICITY
SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism
期刊论文
http://dx.doi.org/10.1016/j.jhep.2011.07.015, 2012
Chen, Tenghui
;
Chen, Qiang
;
Xu, Yixiang
;
Zhou, Qiling
;
Zhu, Jingwei
;
Zhang, Hao
;
Wu, Qiao
;
Xu, Jianming
;
Yu, Chundong
;
吴乔
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2013/12/12
CONSTITUTIVE ANDROSTANE RECEPTOR
NUCLEAR RECEPTOR
IN-VIVO
TRANSCRIPTIONAL COACTIVATOR
LIVER HYPERPLASIA
MITOGEN TCPOBOP
INDUCTION
FAMILY
MICE
HEPATOTOXICITY
Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice
期刊论文
Journal of Ethnopharmacology, 2011, 卷号: 138, 期号: 1, 页码: 111-118
作者:
Guo, Ying
;
Pope, Chad
;
Cheng, Xingguo
;
Zhou, Honghao*
;
Klaassen, Curtis D.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Berberine
Liver
Drug–drug interactions
AhR
aryl hydrocarbon receptor
CAR
constitutive androstane receptor
CYP
Cytochrome P450
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
HLM
human liver microsomes
HNF
hepatocyte nuclear factor
HPLC–MS
high-performance liquid chromatography–tandem mass spectrometry
MDR1a
multi-drug-resistance 1a
MLm
mouse liver microsomes
PPARα
peroxisome proliferator-activated receptor alpha
PXR
pregnane X receptor
RT-PCR
reverse transcription-quantitative polymerase chain reaction
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