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Structural basis of GPBAR activation and bile acid recognition
期刊论文
NATURE, 2020, 页码: 29
作者:
Yang, Fan
;
Mao, Chunyou
;
Guo, Lulu
;
Lin, Jingyu
;
Ming, Qianqian
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019, 期号: 10, 页码: 1396-1411
作者:
Xie, Cen
;
Takahashi, Shogo
;
Brocker, Chad N.
;
He, Shijun
;
Chen, Li
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Peroxisome proliferator-activated receptor alpha
Wy-14,643
Bile acid homeostasis
Farnesoid X receptor
Metabolomics
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1
期刊论文
Biological Chemistry, 2019, 卷号: Vol.400 No.5, 页码: 625-628
作者:
Fan L.
;
Joseph J.F.
;
Durairaj P.
;
Parr M.K.
;
Bureik M.
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/11/21
bile acid
cytochrome P450
fission yeast
liver
S. pombe
steroid hydroxylation
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency
期刊论文
2019, 卷号: 14, 页码: 301-315
作者:
Li, Ying
;
Yang, Dandan
;
Wang, Yian
;
Li, Zhan
;
Zhu, Chunyan
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/01/03
doxorubicin
silybin
hepatic targeting via oral administration
cholic acid transporter
anti-hepatoma
biodistribution in vivo
magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 004, 页码: 507
作者:
Jing Zhao
;
Qingli Zhang
;
Jianhua Shen
;
Kai Wang
;
Jia Liu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
magnesium
lithospermate
B
diabetic
nephropathy
intestinal
microbiota
bile
acid
Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp
期刊论文
FRONTIERS IN MICROBIOLOGY, 2018, 卷号: 9, 期号: 1, 页码: 13
作者:
Xiong, Fan
;
Wu, Shan-Gong
;
Zhang, Jing
;
Jakovlic, Ivan
;
Li, Wen-Xiang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/07/02
bile acid
gut microbiota
lipid metabolism
freshwater fish
in vivo
Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp
期刊论文
FRONTIERS IN MICROBIOLOGY, 2018, 卷号: 9, 页码: 13
作者:
Wang, Gui-Tang
;
Li, Ming
;
Zou, Hong
;
Li, Wen-Xiang
;
Jakovlic, Ivan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2018/12/29
bile acid
gut microbiota
lipid metabolism
freshwater fish
in vivo
Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhao, Jing
;
Zhang, Qing-Li
;
Shen, Jian-Hua
;
Wang, Kai
;
Liu, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
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