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复旦大学上海医学院 [3]
上海药物研究所 [2]
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期刊论文 [14]
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Revealing the Positive Binding Cooperativity Mechanism between the Orthosteric and the Allosteric Antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 628-637
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Hongli
;
Zhang, Qianqian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/01/18
CC chemokine receptor 2
orthosteric antagonist
allosteric antagonist
binding cooperativity
metadynamics simulation
Gaussian accelerated MD simulation
CC chemokine receptor 2 functions in osteoblastic transformation of valvular interstitial cells
期刊论文
2019, 卷号: 228, 页码: 72-84
作者:
Zhu, Enyi
;
Liu, Zihao
;
He, Wanbing
;
Deng, Bingqing
;
Shu, Xiaorong
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
CCR2
Calcified aortic valve disease
Aortic valvular interstitial cells
PI3K/Akt signaling
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3559-3572
作者:
Qin, Li-Huai
;
Wang, Zhi-Long
;
Xie, Xin
;
Long, Ya-Qiu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
6,7,8,9-Tetrahydro-5H-pyrido[43-c]azepin-5-one
3,4-Dihydro-2,6-naphthyridin-1(2H)-one
CCR2 antagonist
Scaffold hopping
Structure-activity relationship
Selectivity of CCR2 over CCR5
The dual CCR2/CCR5 chemokine receptor antagonist Cenicriviroc reduces macrophage infiltration and disease severity in Duchenne muscular dystrophy (Dmd(mdx-4Cv)) mice
期刊论文
PLOS ONE, 2018, 卷号: 13
作者:
Liang, Feng
;
Giordano, Christian
;
Shang, Dong
;
Li, Qian
;
Petrof, Basil J.
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  |  
浏览/下载:4/0
  |  
提交时间:2019/11/26
Evaluation of IL-17A, IL-17F, IL-23R, VDR, CCL2, CCL5, CCR2, and CCR5 gene polymorphisms and expression in Chinese individuals with syphilis
期刊论文
2018, 卷号: 119, 期号: 12, 页码: 10151-10164
作者:
Hu, Wen-Long
;
Ren, Hong
;
Xu, Bu-Fang
;
Zhang, Jing-Ping
;
Zhang, Rui-Li
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
chemokine/chemokine receptor genes
polymorphisms
syphilis
T-helper type 17-related genes
vitamin D receptor gene
CCR2 mediates Helicobacter pylori-induced immune tolerance and contributes to mucosal homeostasis
期刊论文
HELICOBACTER, 2017, 卷号: 22, 期号: 2
作者:
Sun, Xia
;
Zhang, Min
;
El-Zaatari, Mohamad
;
Huffnagle, Gray B.
;
Kao, John Y.
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/12
adaptive immunity
Chemokine receptor 2
dendritic cells
immature
immune tolerance
High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 17
作者:
Li, Ruochen
;
Zhang, Heng
;
Liu, Hao
;
Lin, Chao
;
Cao, Yifan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/13
gastric cancer
CCR2
overall survival
prognosis
biomarker
Pharmacophore Model-based Design and Synthesis of New Structure Small Molecule CCR2 Inhibitors
期刊论文
ACTA CHIMICA SINICA, 2015, 卷号: 73, 期号: 7, 页码: 679-684
作者:
Qin Lihuai
;
Li Xiaoguang
;
Wang Zhilong
;
Yao Wenbo
;
Wang Hui
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
chemokine receptor CCR2
small molecule antagonist
pharmacophore
N-(3-aminocyclopentanecarbox-amido)methyl)benzamide
RNAi Targeting of CCR2 Gene Expression Induces Apoptosis and Inhibits the Proliferation, Migration, and Invasion of PC-3M Cells
期刊论文
ONCOLOGY RESEARCH, 2013, 卷号: 21, 期号: 2
作者:
Gao, Ji
;
Wang, Anna
;
Zhang, Muchun
;
Li, Hongyan
;
Wang, Kaichen
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
RNA interference
CC chemokine receptor 2 (CCR2)
Prostate cancer cells
Apoptosis
Metastasis
Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain
期刊论文
JOURNAL OF NEUROINFLAMMATION, 2012, 卷号: 9
作者:
Zhang, Zhi-Jun
;
Dong, Yu-Lin
;
Lu, Ying
;
Zhao, Zhi-Qi
;
Gao, Yong-Jing
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/19
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