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上海药物研究所 [42]
昆明植物研究所 [11]
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Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
期刊论文
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:
Xu, Jianghong
;
Hu, Yuanyuan
;
Liu, Xiaoqi
;
Gao, Anhui
;
Gao, Lixin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/12/01
IDH1-R132H inhibitors
synthesis
biological activity
docking
3-(indol-3-yl)-4-(pyrazolo-[3
4-c]pyridazin-3-yl)-maleimides
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
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  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Bioassay-guided isolation of antioxidant, antimicrobial, and antiviral constituents of Cordia dichotoma fruits
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 172, 期号: 11, 页码: 1-12
作者:
Yaermaimaiti, S (Yaermaimaiti, Saimijiang) 1 , 2 , 3
;
Wu, T (Wu, Tao) 1 , 2
;
Aisa, HA (Aisa, Haji Akber) 1 , 2 , 3
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  |  
浏览/下载:28/0
  |  
提交时间:2021/12/06
Cordia dichotoma
Bioassay-guided isolation
Phenolics constituents
Structure-activity relationships
Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin
期刊论文
STEROIDS, 2020, 卷号: 164, 页码: 11
作者:
Zhou, Yang
;
Hou, Jinjun
;
Long, Huali
;
Zhang, Zijia
;
Lei, Min
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  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Cardiac glycosides
Cinobufagin
Natural product
Cytotoxicity
Antiproliferative activities
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase
期刊论文
ACS INFECTIOUS DISEASES, 2020, 卷号: 6, 期号: 11, 页码: 2994-3003
作者:
Butler, Joshua H.
;
Baptista, Rodrigo P.
;
Valenciano, Ana L.
;
Zhou, Bin
;
Kissinger, Jessica C.
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  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Plasmodium
PfPARE
structure-resistance relationship study
Malaria Box
Pathogen Box
lindenane sesquiterpenoid dimers
Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 15, 页码: 8442-8457
作者:
Yang, Teng
;
Zhang, Tao
;
Guan, Xiang-Na
;
Dong, Ze
;
Lan, Lefu
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  |  
浏览/下载:19/0
  |  
提交时间:2020/12/24
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
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  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
A structure-activity relationship study of phenyl sesquiterpenoids on efflux inhibition against Staphylococcus aureus
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 8
作者:
Mu, Qing
;
Sun, Zhong-Lin
;
Liu, Tao
;
Gibbons, Simon
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/12/05
Ferula ferulioides
Acetophenone derivatives
Structure-activity relationships
Drug-resistant Staphylococcus aureus
Efflux pump inhibition
Inhibition of UGT1A1 by natural and synthetic flavonoids
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 126
作者:
Fan, Bin
;
Ge, Guang-Bo
;
Tang, Hui
;
Cao, Yun-Feng
;
Finel, Moshe
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  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
Flavonoids
UGT1A1
Structure-inhibition relationships
Inhibition of UGT1A1 by natural and synthetic flavonoids
期刊论文
International journal of biological macromolecules, 2019, 卷号: 126, 页码: 653-661
作者:
Liu Xin-Yu[1]
;
Lv Xia[2]
;
Wang Ping[3]
;
Ai Chun-Zhi[4]
;
Zhou Qi-Hang[5]
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
Flavonoids
Structure-inhibition relationships
UGT1A1
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