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New 8-prenylated quercetin glycosides from the flowers of Epimedium acuminatum and their testosterone production-promoting activities
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Zhang, Yixin
;
Zhang, Cheng
;
Li, Zihan
;
Zeng, Cheng
;
Xue, Zhen
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浏览/下载:0/0
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提交时间:2024/03/07
Epimedium flavonols
phytochemical investigation
flowers
testosterone production
structure-activity relationship
Epimedium acuminatum
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
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浏览/下载:46/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Identification of novel anti-inflammatory Nur77 modulators by virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7
作者:
Ding, Xiaoyu
;
Zhao, Zijie
;
Wu, Yue
;
Zhang, Hao
;
Chen, Kaixian
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  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Nur77
Binding site evaluation
Virtual Screening
Inflammation
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 6, 页码: 991-1002
作者:
Lu, Yan
;
Liu, Hongyue
;
Yang, Dehua
;
Zhong, Li
;
Xin, Ye
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  |  
浏览/下载:25/0
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提交时间:2021/08/17
Total and Semisyntheses of Polymyxin Analogues with 2-Thr or 10-Thr Modifications to Decipher the Structure-Activity Relationship and Improve the Antibacterial Activity
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 9, 页码: 5746-5765
作者:
Li, Jian
;
Guan, Dongliang
;
Chen, Feifei
;
Shi, Weiwei
;
Lan, Lefu
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浏览/下载:35/0
  |  
提交时间:2021/08/17
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16
作者:
Xu, Biao
;
Wang, Zhi-Peng
;
Liu, Qingwang
;
Yang, Xiaohong
;
Li, Xuemin
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浏览/下载:23/0
  |  
提交时间:2021/05/17
Pyruvate dehydrogenase kinase
Proliferation
Cancer metabolism
Structure-activity relationship
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214
作者:
Xu, Biao
;
Wang, Zhi-Peng
;
Liu, Qingwang
;
Yang, Xiaohong
;
Li, Xuemin
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  |  
浏览/下载:24/0
  |  
提交时间:2021/04/26
Pyruvate dehydrogenase kinase
Proliferation
Cancer metabolism
Structure-activity relationship
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:
Wang, Congcong
;
Zhang, Yu-Fang
;
Guo, Shimeng
;
Zhao, Quan
;
Zeng, Yanping
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  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:
Huang, Huoming
;
Li, Xinwei
;
Guo, Wei
;
Zhu, Chen
;
Qian, Yuanyuan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
pain
opioid analgesic
SAR
selective MOR agonist
molecular dynamics simulations
Jatrophane diterpenoids as multidrug resistance modulators from Euphorbia sororia.
期刊论文
Bioorganic chemistry, 2021, 卷号: 112, 期号: 7, 页码: 1-13
作者:
Yang, Hequn
;
Mamatjan, Aytilla
;
Tang, Dan
;
Aisa, Haji Akber
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  |  
浏览/下载:55/0
  |  
提交时间:2021/05/27
Euphorbia sororia
Jatrophane diterpenoids
Mechanisms
Multidrug resistance modulators
P-glycoprotein
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