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科研机构
复旦大学上海医学院 [27]
上海有机化学研究所 [2]
河南大学 [2]
昆明医科大学 [1]
内容类型
期刊论文 [31]
会议论文 [1]
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2019 [3]
2018 [2]
2017 [1]
2016 [3]
2015 [4]
2014 [5]
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计算机化学 [2]
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浏览/检索结果:
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Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
期刊论文
EXPERIMENTAL NEUROLOGY, 2019, 卷号: 311
作者:
Lu, Mei-Hong
;
Ji, Wen-Li
;
Xu, De-En
;
Yao, Pei-Pei
;
Zhao, Xiu-Yun
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/04
BACE1
Sphingomyelin
Amyloid-beta
Lysosomal degradation
Alzheimer's disease
Lipids
Design and Synthesis of the Diazirine-based Clickable Photo-Affinity Probe Targeting Sphingomyelin Synthase 2
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 6
作者:
Wang, Penghui
;
Li, Zhining
;
Jiang, Lulu
;
Zhou, Lu
;
Ye, Deyong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
sphingomyelin
photo-affinity labeling
diazirine
phosphatidylcholine
phosphoethanolamine
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163
作者:
Li, Yali
;
Huang, Taomin
;
Lou, Bin
;
Ye, Deyong
;
Qi, Xiangyu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
Inhibitor
ApoE KO mice
Atherosclerosis
Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 18
作者:
Mo, Mingguang
;
Yang, Jintong
;
Jiang, Xian-Cheng
;
Cao, Yu
;
Fei, Jinyu
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 47
作者:
Lou, Bin
;
Liu, Qi
;
Hou, Jiahui
;
Kabir, Inamul
;
Liu, Peipei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/05
sphingolipid
phospholipid
lipid
lipid metabolism
cancer
2-hydroxy-oleic acid (2OHOA)
anti-cancer drug
lysophosphatidylcholine acyltransferase (LPCAT)
sphingomyelin synthase (SMS)
sphingomyelin
phosphatidylcholine
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 15
作者:
Qi, Xiang-Yu
;
Cao, Yang
;
Li, Ya-Li
;
Mo, Ming-Guang
;
Zhou, Lu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase 2
Anti-atherosclerosis
Oxazolopyridine
Selective inhibitor
SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells
期刊论文
CELL BIOLOGY AND TOXICOLOGY, 2016, 卷号: 32, 期号: 6
作者:
Jin, Guiying
;
Li, Yang
;
Zhu, Yuwen
;
Du, Lisha
;
Yan, Junkai
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Sphingomyelin synthase
P-glycoprotein
Multidrug resistance protein 2
Pregnane X receptor
Phosphorylated signal pathways
Chinese hamster ovary-sphingomyelin synthase2 biospecific extraction and liquid chromatography with tandem mass spectrometry analysis for the prediction of bioactive components of Rhizoma Polygoni Cuspidati
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2016, 卷号: 39, 期号: 6
作者:
Dong, Jibin
;
Liang, Jianying
;
Xue, Ying
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Bioactive candidates
Biospecific extraction
Rhizoma Polygoni Cuspidati
Screening
Traditional Chinese medicine
Novel Dual Inhibitors of Secretory Phospholipase A(2) and Sphingomyelin Synthase: Design, Synthesis and Evaluation
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 卷号: 13, 期号: 10
作者:
Gong, Haojun
;
Zhou, Lu
;
Ye, Deyong
;
Gao, Xing
;
Li, Yali
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/06
Atherosclerosis
secretory phospholipase A(2) (sPLA(2))
sphingomyelin synthase (SMS)
dual inhibitors
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors
期刊论文
Bioorg. Med. Chem., 2015, 卷号: 23, 期号: 18, 页码: 6173-6184
作者:
Li YL(李亚莉)
;
Qi XY(齐翔宇)
;
Jiang H(蒋慧)
;
Deng XD(邓小东)
;
Dong YP(董艳萍)
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2016/12/06
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