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科研机构
上海药物研究所 [14]
厦门大学 [1]
北京大学 [1]
昆明植物研究所 [1]
内容类型
期刊论文 [17]
发表日期
2021 [3]
2019 [1]
2016 [1]
2015 [1]
2013 [4]
2012 [1]
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Chemistry,... [1]
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浏览/检索结果:
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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 13
作者:
Zhang, Huibing
;
Chen, Li-Nan
;
Yang, Dehua
;
Mao, Chunyou
;
Shen, Qingya
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/11/04
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
收藏
  |  
浏览/下载:113/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 1, 页码: 27-33
作者:
Wang, Lei
;
Qiao, Guan-Hua
;
Hu, Hai-Ning
;
Gao, Zhao-Bing
;
Nan, Fa-Jun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
KCNQ channel
retigabine
subtype selectivity
agonist
Discovery of Potent and Selective Agonists of delta Opioid Receptor by Revisiting the "Message-Address" Concept
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 7, 期号: 4, 页码: 391-396
作者:
Shen, Qing
;
Qian, Yuanyuan
;
Huang, Xiaoqin
;
Xu, Xuejun
;
Li, Wei
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
delta opioid receptor
agonist
affinity
selectivity
molecular docking
Nucleotides Acting at P2Y Receptors: Connecting Structure and Function
期刊论文
MOLECULAR PHARMACOLOGY, 2015, 卷号: 88, 期号: 2, 页码: 220-230
作者:
Jacobson, Kenneth A.
;
Paoletta, Silvia
;
Katritch, Vsevolod
;
Wu, Beili
;
Gao, Zhan-Guo
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 卷号: 82, 期号: 3, 页码: 326-335
作者:
Du, Peng
;
Xu, Lili
;
Huang, Jiye
;
Yu, Kunqian
;
Zhao, Rui
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
dopamine 3 receptor
indolebutylamine
pharmacophore model
selectivity
structure-activity relationship
Positive allosteric modulators to peptide GPCRs: a promising class of drugs
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 7, 页码: 880-885
作者:
Bartfai, Tamas
;
Wang, Ming-wei
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
neuropeptide
galanin
GPCR
allosteric mudulation
CYM2503
anticonvulsant
drug screening
Discovery of natural estrogen receptor modulators with structure-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 11, 页码: 3329-3333
作者:
Cao, Xianwen
;
Jiang, Jing
;
Zhang, Shoude
;
Zhu, Lili
;
Zou, Juan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2013/07/24
Molecular docking
Natural product
Estrogen receptor
Virtual screening
Modular Enantioselective Synthesis of 8-Aza-prostaglandin E-1
期刊论文
http://dx.doi.org/10.1021/jo401412g, 2013
Wang, Xiao-Gang
;
Wang, Ai-E
;
Hao, Yi
;
Ruan, Yuan-Ping
;
Huang, Pei-Qiang
;
王爱娥
;
黄培强
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/07/22
INTERMOLECULAR ADDITION-REACTIONS
SUBTYPE-SELECTIVE AGONISTS
OLEFIN CROSS-METATHESIS
EP4 RECEPTOR
STEREOSELECTIVE-SYNTHESIS
PROSTAGLANDIN ANALOGS
ASYMMETRIC-SYNTHESIS
METHYL-ESTER
DISCOVERY
POTENT
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