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Crosstalk between CYP2E1 and PPAR alpha substrates and agonists modulate adipose browning and obesity
期刊论文
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2224-2238
作者:
Zhang, Youbo
;
Yan, Tingting
;
Wang, Tianxia
;
Liu, Xiaoyan
;
Hamada, Keisuke
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/07/19
CYP2E1
PPAR alpha
FGF21
Metabolic enzyme
Nuclear receptor
Obesity
The Pros and Cons of Soybean Bioactive Compounds: An Overview
期刊论文
FOOD REVIEWS INTERNATIONAL, 2022
作者:
Swallah, Mohammed Sharif
;
Yang, Xiaoqing
;
Li, Jiaxin
;
Korese, Joseph Kudadam
;
Wang, Sainan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Bioactive compounds
cancer
cholesterol
immune
isoflavones
peptides
soybean
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
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  |  
浏览/下载:28/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
Liquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202
作者:
Li, Na
;
Mao, Weimin
;
Gao, Yun
;
Wang, Ding
;
Song, Zhengbo
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  |  
浏览/下载:49/0
  |  
提交时间:2021/08/31
Lung cancer
EGFR-TKI
Resistance
Pleural effusion
Metabolomics
Biomarker
Systematic investigation on the anti-rheumatoid arthritis material basis and mechanism of Juan Bi Tang. Part 1: Integrating metabolic profiles and network pharmacology
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202, 页码: 11
作者:
Li, Jiajia
;
Li, Lei
;
Wang, Yangyang
;
Zhao, Yuxuan
;
Hu, Pei
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  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
Juanbi-Tang (JBT)
Rheumatoid arthritis (RA)
Metabolites
Mass
Network pharmacology
Molecular docking
Integrative omic analysis reveals the improvement of alkaloid accumulation by ultraviolet-B radiation and its upstream regulation in Catharanthus roseus
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 166
作者:
Zhong, Zhuoheng
;
Liu, Shengzhi
;
Han, Songling
;
Li, Yaohan
;
Tao, Minglei
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  |  
浏览/下载:92/0
  |  
提交时间:2021/06/15
Mitochondrial respiratory complex
Catharanthus roseus
Ultraviolet B
Alkaloids
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
A systematic strategy integrating solid-phase extraction, full scan range splitting, mass defect filter and precursor ion list for comprehensive metabolite profiling of Danqi Tongmai tablet in rats
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 9
作者:
Li, Zhen-wei
;
Wei, Wen-long
;
Li, Hao-jv
;
Wu, Shi-fei
;
Huang, Yong
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/05/24
Metabolite profiling
Solid-phase extraction
Mass defect filter
Precursor ion list
Danqi Tongmai tablet
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:131/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
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