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Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells
期刊论文
Molecules, 2022, 卷号: 21, 期号: 27, 页码: 7490
作者:
Chun-Yan Sang
;
Yi-Dan Zheng
;
Li-Mei Ma
;
Li-Mei Ma
;
Cheng-Bo Wang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/12/07
natural products
Nardostachys jatamansi DC.
pancreatic cancer
iTRAQ/TMT
MET/PTEN/TGF-β pathway
Terpenoids from Nardostachys jatamansi and Their Cytotoxic Activity against Human Pancreatic Cancer Cell Lines
期刊论文
Phytochemistry, 2022, 期号: 200, 页码: 113228
作者:
Li-Mei Ma
;
Kai Wang
;
Xian-Hua Meng
;
Yi-Dan Zheng
;
Cheng-Bo Wang
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2022/11/30
Nardostachys jatamansi DC.
Valerianaceae
Terpenoids
Cytotoxicity
Human pancreatic cancer cell lines
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213
作者:
Zheng Zhang
;
Dai Chengqiu
;
Wu Honghong
;
Li Jingya
;
Nan Fajun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
death associated apoptotic protein kinase 2
diabetes
alkylphenols
inhibitors
The phosphatidylserine flippase beta-subunit Tmem30a is essential for normal insulin maturation and secretion
期刊论文
MOLECULAR THERAPY, 2021, 卷号: 29, 期号: 9
作者:
Yang, Yeming
;
Sun, Kuanxiang
;
Liu, Wenjing
;
Li, Xiao
;
Tian, Wanli
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  |  
浏览/下载:29/0
  |  
提交时间:2021/11/18
A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 162, 页码: 107-115
作者:
Bian, Youcheng
;
Zeng, Hui
;
Tao, Hong
;
Huang, Lulin
;
Du, Zhenyun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
Polygala tenuifolia
Pectin
Pancreatic cancer
Apoptosis
Autophagy
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:
Luo, Jiao
;
Zheng, Meiling
;
Jiang, Bo
;
Li, Chao
;
Guo, Shuju
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2020/09/29
bromophenol
PTP1B inhibitor
selectivity
cell permeability
oral bioavailability
DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Huang, Jun-shang
;
Guo, Bin-bin
;
Wang, Gai-hong
;
Zeng, Li-min
;
Hu, You-hong
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/12/24
type 2 diabetes
DGAT1 inhibitors
pancreatic beta-cells
apoptosis
ER stress
inflammation
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188, 页码: 17
作者:
Wang, Junwei
;
Lv, Xue
;
Xu, Jiawen
;
Liu, Xinpeng
;
Du, Te
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Type 2 diabetes mellitus
Pancreatic beta-cells protective agents
Vincamine derivatives
Structural modifications
Structure-activity relationships
Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis
期刊论文
Chinese Medicine, 2020, 卷号: 15, 期号: 1, 页码: 1-12.
作者:
Xi Liu
;
Qiong Li
;
Xiaolei Cheng
;
Zhichun Liu
;
Xiaoliang Zhao
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/03/10
Oligomannuronate
Type 2 diabetes
Islet amyloid polypeptide
JNK activation
Mitochondrial dysfunction
RINm5F cells
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