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浏览/检索结果: 共1条，第1-1条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文 Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140 作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong* 收藏  |  浏览/下载：13/0  |  提交时间：2019/12/23 Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma