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浏览/检索结果: 共8条，第1-8条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA(H1047R) accompanied with pro-tumorigenic secretome 期刊论文 INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 817-829 作者:  Liu, Xue-Ling;  Liu, Jia-Li;  Xu, Yi-Chao;  Zhang, Xi;  Wang, Yu-Xiang 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 PI3K alpha  membrane metallo-endopeptidase  senescence  macrophage  breast cancer   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree 收藏  |  浏览/下载：84/0  |  提交时间：2019/01/08 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Tang, Qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Proliferation  Anticancer drug  Phosphatidylinositol 3-kinase inhibitor  Apoptosis  Structure-activity relationship   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K alpha-selective inhibitor CYH33 in breast cancer 期刊论文 CANCER LETTERS, 2018, 卷号: 433, 页码: 273-282 作者:  Liu, Xue-ling;  Xu, Yi-chao;  Wang, Yu-xiang;  Chen, Yi;  Wang, Bo-bo 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 PIK3CA  HER2  Akt  Patient-derived xenograft (PDX)   DW09849, a Selective Phosphatidylinositol 3-Kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation p110 alpha (H1047R) 期刊论文 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 卷号: 348, 期号: 3, 页码: 432-441 作者:  Liu, Jia-li;  Gao, Guo-rui;  Zhang, Xi;  Cao, Su-fen;  Guo, Chen-liang 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 WJD008, a Dual Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin Inhibitor, Prevents PI3K Signaling and Inhibits the Proliferation of Transformed Cells with Oncogenic PI3K Mutant 期刊论文 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 卷号: 334, 期号: 3, 页码: 830-838 作者:  Li, Ting;  Wang, Jia;  Wang, Xiang;  Yang, Na;  Chen, Si-meng 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08