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上海药物研究所 [6]
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期刊论文 [14]
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Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:
Hu, Li-Peng
;
Zhang, Xiao-Xin
;
Jiang, Shu-Heng
;
Tao, Ling-Ye
;
Li, Qing
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/12/02
adenosine triphosphate
ar c118925xx
gemcitabine
glucose transporter 1
hypoxia inducible factor 1alpha
Myc protein
platelet derived growth factor beta receptor
platelet derived growth factor receptor
protein kinase Yes
purinergic P2Y receptor antagonist
purinergic P2Y2 receptor
unclassified drug
Yes1 protein, Akt signaling
animal experiment
animal model
animal tissue
Article
cancer inhibition
cancer prognosis
cancer staging
controlled study
drug potentiation
glycolysis
human
human cell
human tissue
inflammation
lymph node metastasis
male
mouse
mouse model
nonhuman
overall survival
pancreas adenocarcinoma
pancreatic ductal carcinoma cell line
Pi3K/Akt signaling
priority journal
RNA sequence
tumor classification
tumor differentiation
tumor microenvironment
tumor volume
tumor xenograft
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor
期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2018, 卷号: 14, 期号: 5, 页码: 2761-2770
作者:
Yuan, Xiaojing
;
Raniolo, Stefano
;
Limongelli, Vittorio
;
Xu, Yechun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
In silico Approach for Anti-Thrombosis Drug Discovery:P2Y(1)R Structure-Based TCMs Screening
期刊论文
2017, 卷号: 7, 页码: 531
作者:
Yi, Fan
;
Sun, Le
;
Xu, Li-jia
;
Peng, Yong
;
Liu, Hai-bo
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Traditional Chinese medicines
P2Y(1)R
anti-thrombosis
platelet aggregation
in silico screening
Structural Studies of G Protein-Coupled Receptors
期刊论文
IUBMB LIFE, 2016, 卷号: 68, 期号: 11, 页码: 894-903
作者:
Lu, Mengjie
;
Wu, Beili
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
G protein-coupled receptor
structural studies
chemokine receptor
purinergic receptor
Nucleotides Acting at P2Y Receptors: Connecting Structure and Function
期刊论文
MOLECULAR PHARMACOLOGY, 2015, 卷号: 88, 期号: 2, 页码: 220-230
作者:
Jacobson, Kenneth A.
;
Paoletta, Silvia
;
Katritch, Vsevolod
;
Wu, Beili
;
Gao, Zhan-Guo
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Two disparate ligand-binding sites in the human P2Y(1) receptor
期刊论文
NATURE, 2015, 卷号: 520, 期号: 7547, 页码: 317-+
作者:
Zhang, Dandan
;
Gao, Zhan-Guo
;
Zhang, Kaihua
;
Kiselev, Evgeny
;
Crane, Steven
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Structure of the human P2Y(12) receptor in complex with an antithrombotic drug
期刊论文
NATURE, 2014, 卷号: 509, 期号: 7498, 页码: 115-118
作者:
Zhang, Kaihua
;
Zhang, Jin
;
Gao, Zhan-Guo
;
Zhang, Dandan
;
Zhu, Lan
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Agonist-bound structure of the human P2Y(12) receptor
期刊论文
NATURE, 2014, 卷号: 509, 期号: 7498, 页码: 119-122
作者:
Zhang, Jin
;
Zhang, Kaihua
;
Gao, Zhan-Guo
;
Paoletta, Silvia
;
Zhang, Dandan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Salvianolic acid B inhibits platelets as a P2Y(12) antagonist and PDE inhibitor: Evidence from clinic to laboratory
期刊论文
THROMBOSIS RESEARCH, 2014, 卷号: 134, 期号: 4, 页码: 866-876
作者:
Liu, L
;
Li, J
;
Zhang, Y
;
Zhang, SH
;
Ye, JQ
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2015/07/22
acute coronary syndrome
antiplatelet
P2Y(12) receptor antagonist
phosphodiesterase inhibitor
salvianolate
Heterosynaptic long-term depression mediated by ATP released from astrocytes
期刊论文
GLIA, 2013, 卷号: 61, 期号: 2, 页码: 178-191
Chen, JD
;
Tan, ZB
;
Zeng, L
;
Zhang, XX
;
He, Y
;
Gao, W
;
Wu, XM
;
Li, YJ
;
Bu, BT
;
Wang, W
;
Duan, SM
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2013/06/04
CULTURED HIPPOCAMPAL-NEURONS
GLIAL-CELLS
SYNAPTIC-TRANSMISSION
D-SERINE
GLUTAMATE RELEASE
CALCIUM WAVES
POTENTIATION
STIMULATION
PLASTICITY
RECEPTOR
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