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CORC

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Update of P2Y receptor pharmacology: IUPHAR Review 27 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 11, 页码: 2413-2433
作者:  Jacobson, Kenneth A.;  Delicado, Esmerilda G.;  Gachet, Christian;  Kennedy, Charles;  von Kuegelgen, Ivar
收藏  |  浏览/下载：61/0  |  提交时间：2020/07/01
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3088-3106
作者:  Kong, Deyu;  Xue, Tao;  Guo, Bin;  Cheng, Jianjun;  Liu, Shunyin
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis 期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:  Hu, Li-Peng;  Zhang, Xiao-Xin;  Jiang, Shu-Heng;  Tao, Ling-Ye;  Li, Qing
收藏  |  浏览/下载：31/0  |  提交时间：2019/12/02
adenosine triphosphate  ar c118925xx  gemcitabine  glucose transporter 1  hypoxia inducible factor 1alpha  Myc protein  platelet derived growth factor beta receptor  platelet derived growth factor receptor  protein kinase Yes  purinergic P2Y receptor antagonist  purinergic P2Y2 receptor  unclassified drug  Yes1 protein, Akt signaling  animal experiment  animal model  animal tissue  Article  cancer inhibition  cancer prognosis  cancer staging  controlled study  drug potentiation  glycolysis  human  human cell  human tissue  inflammation  lymph node metastasis  male  mouse  mouse model  nonhuman  overall survival  pancreas adenocarcinoma  pancreatic ductal carcinoma cell line  Pi3K/Akt signaling  priority journal  RNA sequence  tumor classification  tumor differentiation  tumor microenvironment  tumor volume  tumor xenograft  
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 302-310
作者:  Peng, Jingjing;  Zhao, Lifen;  Wang, Lanlan;  Chen, Hui;  Qiu, Yunguang
收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08
Structural basis for signal recognition and transduction by platelet-activating-factor receptor 期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 卷号: 25, 期号: 6, 页码: 488-+
作者:  Cao, Can;  Tan, Qiuxiang;  Xu, Chanjuan;  He, Lingli;  Yang, Linlin
收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor 期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2018, 卷号: 14, 期号: 5, 页码: 2761-2770
作者:  Yuan, Xiaojing;  Raniolo, Stefano;  Limongelli, Vittorio;  Xu, Yechun
收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08
Ligand binding to a G protein-coupled receptor captured in a mass spectrometer 期刊论文
SCIENCE ADVANCES, 2017, 卷号: 3, 期号: 6
作者:  Yen, Hsin-Yung;  Hopper, Jonathan T. S.;  Liko, Idlir;  Allison, Timothy M.;  Zhu, Ya
收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08
Two disparate ligand-binding sites in the human P2Y(1) receptor 期刊论文
NATURE, 2015, 卷号: 520, 期号: 7547, 页码: 317-+
作者:  Zhang, Dandan;  Gao, Zhan-Guo;  Zhang, Kaihua;  Kiselev, Evgeny;  Crane, Steven
收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08
Structure of the human P2Y(12) receptor in complex with an antithrombotic drug 期刊论文
NATURE, 2014, 卷号: 509, 期号: 7498, 页码: 115-118
作者:  Zhang, Kaihua;  Zhang, Jin;  Gao, Zhan-Guo;  Zhang, Dandan;  Zhu, Lan
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
Agonist-bound structure of the human P2Y(12) receptor 期刊论文
NATURE, 2014, 卷号: 509, 期号: 7498, 页码: 119-122
作者:  Zhang, Jin;  Zhang, Kaihua;  Gao, Zhan-Guo;  Paoletta, Silvia;  Zhang, Dandan
收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08

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