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上海药物研究所 [10]
厦门大学 [3]
大连理工大学 [2]
复旦大学上海医学院 [2]
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期刊论文 [23]
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GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:
Wang, Congcong
;
Zhang, Yu-Fang
;
Guo, Shimeng
;
Zhao, Quan
;
Zeng, Yanping
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52
期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 12, 页码: 3275-3284
作者:
Ma, Mengna
;
Guo, Shimeng
;
Lin, Xi
;
Li, Shanshan
;
Wu, Yiran
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 页码: 14
作者:
Mutharasu, Gnanavel
;
Murugesan, Akshaya
;
Konda Mani, Saravanan
;
Yli-Harja, Olli
;
Kandhavelu, Meenakshisundaram
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/10
GPR17
signaling networks
glioblastoma multiforme
RNA-Seq
protein–
protein interface
kinases
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment
期刊论文
SCIENCE ADVANCES, 2020, 卷号: 6, 期号: 18, 页码: 11
作者:
Wang, Leiming
;
Cheng, Chiang-Min
;
Qin, Jun
;
Xu, Mafei
;
Kao, Chung-Yang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Structural basis of ligand recognition and self-activation of orphan GPR52
期刊论文
NATURE, 2020, 页码: 21
作者:
Lin, Xi
;
Li, Mingyue
;
Wang, Niandong
;
Wu, Yiran
;
Luo, Zhipu
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  |  
浏览/下载:170/0
  |  
提交时间:2020/07/01
The orphan nuclear receptor RORα is a potential endogenous protector in renal ischemia/reperfusion injury.
期刊论文
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019
作者:
Jieru Cai
;
Xiaoyan Jiao
;
Yi Fang
;
Xiaofang Yu
;
Xiaoqiang Ding
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/13
AKI
ROR
apoptosis
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes
期刊论文
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:
Song, Haikun
;
Li, Hexuan
;
Guo, Shimeng
;
Pan, Yuyin
;
Fu, Yuhua
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  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
GPCR
target validation
polyQ
neurodegeneration
antagonists
China has officially released its first national list of rare diseases
期刊论文
INTRACTABLE & RARE DISEASES RESEARCH, 2018, 卷号: 7, 期号: 2
作者:
He, Jiangjiang
;
Kang, Qi
;
Hu, Jiahao
;
Song, Peipei
;
Jin, Chunlin
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Rare diseases
disease classification
disease management
orphan drugs
DIGNiFI: Discovering causative genes for orphan diseases using protein-protein interaction networks
期刊论文
BMC SYSTEMS BIOLOGY, 2017, 卷号: 11, 页码: 23
作者:
Liu, Xiaoxia
;
Yang, Zhihao
;
Lin, Hongfei
;
Simmons, Michael
;
Lu, Zhiyong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/02
Orphan disease
Genetic disease
Protein-protein interaction networks
Eye disease
DIGNiFI: Discovering causative genes for orphan diseases using protein-protein interaction networks
会议论文
PROCEEDINGS OF THE 7TH ACM INTERNATIONAL CONFERENCE ON BIOINFORMATICS, COMPUTATIONAL BIOLOGY, AND HEALTH INFORMATICS, 2016-01-01
作者:
Liu, Xiaoxia
;
Yang, Zhihao
;
Lin, Hongfei
;
Simmons, Michael
;
Lu, Zhiyong
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/09
Orphan disease
genetic disease
protein-protein interaction networks
eye disease
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